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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Syktm1.1Tara
targeted mutation 1.1, Alexander Tarakhovsky
MGI:3690645
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Syktm1.1Tara/Syktm1.1Tara involves: 129P2/OlaHsd * C57BL/6 MGI:3696447


Genotype
MGI:3696447
hm1
Allelic
Composition		 Syktm1.1Tara/Syktm1.1Tara
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.1Tara mutation (0 available); any Syk mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:115080 )
• most die around the perinatal stage, although a few survive to adulthood

immune system
increased B cell proliferation ( J:114816 )
• pre-B cells in culture are hyperproliferative in response to IL-7
arrested B cell differentiation ( J:115080 )
• exhibit a block in pro- and pre-B cell development

hematopoietic system
increased B cell proliferation ( J:114816 )
• pre-B cells in culture are hyperproliferative in response to IL-7
arrested B cell differentiation ( J:115080 )
• exhibit a block in pro- and pre-B cell development

cellular
increased B cell proliferation ( J:114816 )
• pre-B cells in culture are hyperproliferative in response to IL-7




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory