Phenotypes associated with this allele

• Allele Symbol: Adgrl1^tm1Sud
• Allele Name: targeted mutation 1, Thomas C Sudhof
• Allele ID: MGI:3691022
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgrl1^tm1Sud/Adgrl1^tm1Sud	involves: 129S6/SvEvTac * C57BL/6	MGI:3691029
cx2	Adgrl1^tm1Sud/Adgrl1^tm1Sud Nrxn1^tm1Sud/Nrxn1^tm1Sud	involves: 129 * 129S6/SvEvTac * C57BL/6	MGI:3691278

Genotype
MGI:3691029

hm1

• Allelic Composition: Adgrl1^tm1Sud/Adgrl1^tm1Sud
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal maternal nurturing ( J:115214 )

♀ • homozygous female mice fail adequately to care for their litters

nervous system

abnormal nervous system physiology ( J:115214 )

• in the absence of Ca²⁺, only about 25% as much ¹²⁵I-alpha-latrotoxin binds to membranes isolated from brains of homozygous mutant mice as from wild-type mice

• in the presence of Ca²⁺, about 50% as much ¹²⁵I-alpha-latrotoxin binds to brain membranes from homozygous mutant mice as from wild-type mice; binding in the presence of Ca²⁺ is approximately 2-fold that in its absence

decreased synaptic glutamate release ( J:115214 )

• although the kinetics of K⁺-depolarization-stimulated glutamate release in the presence of Ca²⁺ from synaptosomes isolated from homozygous mutant and wild-type brains are similar, alpha-latrotoxin-stimulated glutamate release from synaptosomes of mutant brains is reduced to approximately 25% that from wild-type synaptosomes in the presence or absence of Ca²⁺

Genotype
MGI:3691278

cx2

• Allelic Composition: Adgrl1^tm1Sud/Adgrl1^tm1Sud; Nrxn1^tm1Sud/Nrxn1^tm1Sud
• Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

nervous system

abnormal nervous system physiology ( J:115214 )

• in the presence or in the absence of Ca²⁺, the amount of ¹²⁵I-alpha-latrotoxin binding to membranes isolated from brains of doubly homozygous mutant mice is reduced to about 25% of that binding to brain membranes from wild-type mice; approximately twice as much binds in the presence of Ca²⁺ as in its absence

abnormal synaptic glutamate release ( J:115214 )

• although in the presence of Ca²⁺ the kinetics are similar for alpha-latrotoxin-stimulated release of glutamate from doubly mutant and wild-type brain-derived synaptosomes, in the absence of Ca²⁺ the delay to initiation of glutamate release from doubly mutant synaptosomes is prolonged in comparison to that from wild-type and both singly mutant synaptosomes (5 min vs. 2 min)

decreased synaptic glutamate release ( J:115214 )

• in the absence of Ca²⁺, alpha-latrotoxin-stimulated glutamate release from synaptosomes isolated from doubly homozygous mutant brains is reduced to approximately 50% of that from wild-type synaptosomes