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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polhtm2Fmh
targeted mutation 2, Fumio Hanaoka
MGI:3691063
Summary 4 genotypes


Genotype
MGI:3691207
hm1
Allelic
Composition		 Polhtm2Fmh/Polhtm2Fmh
Genetic
Background		 B6.129-Polhtm2Fmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by UV-induction ( J:115000 )
• decreased latency to develop UV-B induced skin tumors (13 weeks)
• after 20 weeks of UV-B exposure 90% of mice display multiple tumors on the dorsal skin and ears compared to no tumor development in wild-type mice

integument
skin photosensitivity ( J:115000 )
• following 5 and 10 weeks of UV-B exposure a incidence of epithelial hyperplasia (6 of 6 at 5 weeks) and dysplasia (3 of 3 at 10 weeks) is increased compared to heterozygous mice (1 of 6 and 0 of 3, respectively)




Genotype
MGI:3691208
ht2
Allelic
Composition		 Polhtm2Fmh/Polh+
Genetic
Background		 B6.129-Polhtm2Fmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by UV-induction ( J:115000 )
• epithelial tumors developed in 5 of 9 mice during a 10 week resting period after 20 weeks of UV-B exposure compared to 0 o8 wild-type mice




Genotype
MGI:3691209
cx3
Allelic
Composition		 Polhtm2Fmh/Polhtm2Fmh
Polid/Polid
Genetic
Background		 B6.129-Polhtm2Fmh Polid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (38 available)
Polid mutation (3 available); any Poli mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of induced tumors ( J:115000 )
• tumors appear 4 weeks earlier and the average number of tumors is slightly but significantly increased compared to mice wild-type for Poli
• lung tumors, considered to be metastasis from skin tumors, were detected in 3 of 19 mice
• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli




Genotype
MGI:3691210
cx4
Allelic
Composition		 Polhtm2Fmh/Polhtm2Fmh
Polid/Poli+
Genetic
Background		 B6.129-Polhtm2Fmh Polid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (38 available)
Polid mutation (3 available); any Poli mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of induced tumors ( J:115000 )
• tumors appear 4 weeks earlier than in mice wild-type for Poli
• lung tumors, considered to be metastasis from skin tumors, were detected in 2 of 16 mice
• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory