About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polhtm2Fmh
targeted mutation 2, Fumio Hanaoka
MGI:3691063
Summary 4 genotypes


Genotype
MGI:3691207
hm1
Allelic
Composition		 Polhtm2Fmh/Polhtm2Fmh
Genetic
Background		 B6.129-Polhtm2Fmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by UV-induction ( J:115000 )
• decreased latency to develop UV-B induced skin tumors (13 weeks)
• after 20 weeks of UV-B exposure 90% of mice display multiple tumors on the dorsal skin and ears compared to no tumor development in wild-type mice

integument
skin photosensitivity ( J:115000 )
• following 5 and 10 weeks of UV-B exposure a incidence of epithelial hyperplasia (6 of 6 at 5 weeks) and dysplasia (3 of 3 at 10 weeks) is increased compared to heterozygous mice (1 of 6 and 0 of 3, respectively)




Genotype
MGI:3691208
ht2
Allelic
Composition		 Polhtm2Fmh/Polh+
Genetic
Background		 B6.129-Polhtm2Fmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by UV-induction ( J:115000 )
• epithelial tumors developed in 5 of 9 mice during a 10 week resting period after 20 weeks of UV-B exposure compared to 0 o8 wild-type mice




Genotype
MGI:3691209
cx3
Allelic
Composition		 Polhtm2Fmh/Polhtm2Fmh
Polid/Polid
Genetic
Background		 B6.129-Polhtm2Fmh Polid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (38 available)
Polid mutation (3 available); any Poli mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of induced tumors ( J:115000 )
• tumors appear 4 weeks earlier and the average number of tumors is slightly but significantly increased compared to mice wild-type for Poli
• lung tumors, considered to be metastasis from skin tumors, were detected in 3 of 19 mice
• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli




Genotype
MGI:3691210
cx4
Allelic
Composition		 Polhtm2Fmh/Polhtm2Fmh
Polid/Poli+
Genetic
Background		 B6.129-Polhtm2Fmh Polid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (38 available)
Polid mutation (3 available); any Poli mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of induced tumors ( J:115000 )
• tumors appear 4 weeks earlier than in mice wild-type for Poli
• lung tumors, considered to be metastasis from skin tumors, were detected in 2 of 16 mice
• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory