Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(tetO-Tek)1Dmt transgene insertion 1, Daniel J Dumont MGI:3691068 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mouse ears contain blood vessels that are more highly branched
• a similar trend is observed for vessels in both dorsal and ventral superficial fascia
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• ears contain 41% more blood vessels and back skin 82% more blood vessels than controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are on average 20-15% smaller than wild-type littermates
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• mice exhibit increased numbers of eosinophils in the dermis
• expression of chemokines associated with eosinophil immune responses is increased in the blood and skin
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• moderate increase in number of CD3+ T cells in the blood
• however, levels of B lymphocytes, myeloid cells, megakaryocytes, and erythrocytes in the blood are normal
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• disruption of the normal red and white pulp architecture
• increase in infiltration of white blood cells such as myeloid cells and megakaryocytes in the red pulp
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• disruption of the normal red and white pulp architecture
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• mice show focal dermal inflammatory infiltrates of mononuclear cells consisting primarily of lymphocytes with dispersed macrophages and mast cells
(J:96718)
• some areas of skin in severely affected mice have aggregates of neutrophilic polymorphonuclear leukocytes that form microabscesses within the epidermis
(J:96718)
• mice show an increase in the number of dermal mast cells and CD3+ T lymphocytes in the dermis
(J:96718)
• mice exhibit increased numbers of eosinophils in the dermis
(J:137745)
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• emerging hair appears dull
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• emerging hair appears sparse
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• severely affected mice display yellow-brown discoloration of the nails
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• in some regions of epidermal thickening, uneven elongation of structures resembling rete pegs extend downward into the dermis; these structures encompass hyperplastic hair follicles
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• mice exhibit larger and more tortuous blood vessels immediately below the epidermis
• horizontal vessels comprising the subpapillary plexus and deeper cutaneous plexus are larger and often extend great distances in close proximity to the hyperproliferative epidermal layer
• increase in density and diameter of blood vessels in the skin, however no change in vessel numbers is seen
• mice treated with doxycycline show reduced vessel diameter and density in the dermis
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• skin has an increased amount and density of cornified material, indicating compact hyperkeratosis
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• skin has areas where nucleated cells are present in the cornified layer, indicating focal parakeratosis
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• severely affected mice exhibit zones of hyperplasia due to variable increases in the number of cell layers in the squamous epithelium indicating acanthosis
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• mild epidermal thickening in the skin of the ear, head, and back
(J:96718)
• mice treated for 2 weeks with an anti-CD4 antibody do not show improved epidermal hyperplasia, indicating that maintenance of the skin disease is not dependent of CD4+ T lymphocytes
(J:137745)
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• beginning at P5, skin shows extensive erythema
(J:96718)
• adults exhibit patches of thickened erythematous skin around the eyes, snout, ears, and other extensor surfaces including the knuckles of the legs and nape of the neck
(J:96718)
• severity of erythema varies
(J:96718)
• within 7 days of treating adult mice with doxycycline, mice show improved erythematous characteristics
(J:96718)
• mice treated for 2 weeks with an anti-CD4 antibody show improved erythema
(J:137745)
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• beginning at P5, skin shows loosely adherent silver-white scaling
• skin is covered with focal areas of scaling that extend to the tail
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• mice show increased genesis of skin lesions at sites of trauma that become large, thickened, and ulcerated
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• skin shows features of psoriasis including epidermal hyperplasia, inflammatory cell accumulation and altered dermal angiogenesis
• within 4 days of doxycycline treatment beginning at P7, mice show improvements in skin and fur appearance
• severely affected mice treated with the immunosuppressive anti-psoriatic agent cyclosporine display improvement in skin phenotype, showing epidermal thinning, reduced dermal cellularity and vascular density
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• dermis exhibits an increase in the number of blood capillaries with dilated and tortuous changes
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• mice exhibit larger and more tortuous blood vessels immediately below the epidermis
• horizontal vessels comprising the subpapillary plexus and deeper cutaneous plexus are larger and often extend great distances in close proximity to the hyperproliferative epidermal layer
• increase in density and diameter of blood vessels in the skin, however no change in vessel numbers is seen
• mice treated with doxycycline show reduced vessel diameter and density in the dermis
|
|
• mice exhibit increased numbers of eosinophils in the dermis
• expression of chemokines associated with eosinophil immune responses is increased in the blood and skin
|
|
• moderate increase in number of CD3+ T cells in the blood
• however, levels of B lymphocytes, myeloid cells, megakaryocytes, and erythrocytes in the blood are normal
|
|
• disruption of the normal red and white pulp architecture
• increase in infiltration of white blood cells such as myeloid cells and megakaryocytes in the red pulp
|
|
• disruption of the normal red and white pulp architecture
|
|
• mice show focal dermal inflammatory infiltrates of mononuclear cells consisting primarily of lymphocytes with dispersed macrophages and mast cells
(J:96718)
• some areas of skin in severely affected mice have aggregates of neutrophilic polymorphonuclear leukocytes that form microabscesses within the epidermis
(J:96718)
• mice show an increase in the number of dermal mast cells and CD3+ T lymphocytes in the dermis
(J:96718)
• mice exhibit increased numbers of eosinophils in the dermis
(J:137745)
|
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• older mice sporadically develop a white opacity of the eye indicating age-related cataract
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| psoriasis | DOID:8893 |
OMIM:PS177900 |
J:96718 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• is increased in the ear and back skin of mice
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• interleukin-22 secretion is increased in the ear and back skin of mice
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• is increased in the ear and back skin of mice
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• is increased in the ear and back skin of mice
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• is increased in the ear and back skin of mice
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• inflammatory infiltrate associated with psoriasis includes CD4+ T cells in the dermis and CD8+ T cells in the epidermis, myeloid dendritic cells, macrophages and granulocytes
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• mouse ears by 21 days of age contain larger blood vessels that are more highly branched
• a similar trend is observed for vessels in both dorsal and ventral superficial fascia
|
|
• ears contain 59% more blood vessels and back skin 102% more blood vessels than controls
|
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• inflammatory infiltrate associated with psoriasis includes CD4+ T cells in the dermis and CD8+ T cells in the epidermis, myeloid dendritic cells, macrophages and granulocytes
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• is observed in the skin and back
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• mouse ears are erythematous by 21 days of age
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• skin begins to develop reddened, scaly, hyperkeratotic lesions between 2 to 6 months of age
• lesions involve hyperplasia of the epidermis, a loss of the granular cell layer, thickening of the interfollicular epidermal layers, confluent parakeratotic scale, increased dermal angiogenesis, and extensive inflammatory infiltration
• dorsal and ventral surfaces, bilateral elbows, and skin surrounding the genital region can develop these lesion
• 73% of mice have lesions involving back and ear, 22% develop just ear lesions, and 5% develop no lesions
• psoriasis can be reversed by treatment with doxycycline or attenuated with cyclosporine A treatment
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• the epidermis is 3.2- and 3.1- fold thicker in the ear and backs, respectively, than in controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| psoriasis | DOID:8893 |
OMIM:PS177900 |
J:147438 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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