Phenotypes associated with this allele

• Allele Symbol: Ssr1^{Gt(ble-lacZl)16Brr}
• Allele Name: gene trap 16, Jacqueline Barra
• Allele ID: MGI:3691069
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ssr1^Gt(ble-lacZl)16Brr/Ssr1^Gt(ble-lacZl)16Brr	involves: 129S2/SvPas	MGI:3691232

Genotype
MGI:3691232

hm1

• Allelic Composition: Ssr1^{Gt(ble-lacZl)16Brr}/Ssr1^{Gt(ble-lacZl)16Brr}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:115006 )

• homozygotes are born but die shortly after birth

growth/size/body

enlarged heart ( J:115006 )

• heart is enlarged with a clear indentation at the apex of the ventricles

decreased fetal size ( J:115006 )

• smaller at E15.5

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:115006 )

• endocardial cushions are frequently detached from the myocardium and show a reduction in the total number of mesenchymal cells at E12.5

• endocardial cushions show an increase in the number of cells in S phase and a small decrease in the number of cells in M phase, suggesting that the cell cycle is lengthened and that mesenchymal cells divide more slowly

• myocardialization of the endocardial cushions is delayed, with no or few cells protruding from the myocardium towards the cushions at E12.5 and E13.5

abnormal truncus arteriosus septation ( J:115006 )

• septation of the proximal part of the outflow tract is absent

• at E15.5, the aorta and pulmonary artery separate distally, but the two large arteries remain side by side, indicating abnormal rotation of the aorta

abnormal heart development ( J:115006 )

failure of conotruncal ridge closure ( J:115006 )

double outlet right ventricle ( J:115006 )

• absence of septum results in the persistence of a common trunk connected to the right ventricle and thus the formation of a double-outlet right ventricle

aorticopulmonary septal defect ( J:115006 )

• absence of septum formation in the proximal part (conus) of the outflow tract

persistent truncus arteriosus ( J:115006 )

• exhibit absence of septum formation in the proximal part (conus) of the outflow tract resulting in persistent truncus arteriosis

enlarged heart ( J:115006 )

• heart is enlarged with a clear indentation at the apex of the ventricles

abnormal semilunar valve morphology ( J:115006 )

• the valve leaflets point down to the ventricle and in most cases, they retain a thick and cushion-like appearance

abnormal heart ventricle morphology ( J:115006 )

abnormal interventricular septum morphology ( J:115006 )

• exhibit incomplete ventricle septation at E12.5 due to the absence of septum formation in the proximal part (conus) of the outflow tract

dilated heart left ventricle ( J:115006 )

dilated heart right ventricle ( J:115006 )

homeostasis/metabolism

edema ( J:115006 )

• develop severe subcutaneous edema by E15.5