Phenotypes associated with this allele

• Allele Symbol: Itga3^tm1Son
• Allele Name: targeted mutation 1, Arnaud Sonnenberg
• Allele ID: MGI:3691084
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd151^tm2Nki/Cd151^tm2Nki Itga3^tm1Son/Itga3^+ Krt14^tm1(cre)Wbm/?	FVB.129P2-Cd151^tm2Nki Itga3^tm1Son Krt14^tm1(cre)Wbm	MGI:5550138
cn2	Itga3^tm1Son/Itga3^tm1Son Tg(KRT5-cre)5132Jlj/?	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:3836770
cn3	Itga3^tm1Son/Itga3^tm1Son Krt14^tm1(cre)Wbm/Krt14^+	involves: 129P2/OlaHsd * FVB/N	MGI:3836769
cn4	Itga3^tm1Son/Itga3^tm1Son Tg(NPHS2-cre)295Lbh/0	Not Specified	MGI:3691146

Genotype
MGI:5550138

cn1

• Allelic Composition: Cd151^tm2Nki/Cd151^tm2Nki; Itga3^tm1Son/Itga3⁺; Krt14^tm1(cre)Wbm/?
• Genetic Background: FVB.129P2-Cd151^tm2Nki Itga3^tm1Son Krt14^tm1(cre)Wbm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

• however, overall benign and malignant histology is normal

decreased tumor growth/size ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

integument

decreased keratinocyte proliferation ( J:205736 )

• in papillomas of DMBA- and TPA-treated mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

• however, overall benign and malignant histology is normal

cellular

decreased keratinocyte proliferation ( J:205736 )

• in papillomas of DMBA- and TPA-treated mice

Genotype
MGI:3836770

cn2

• Allelic Composition: Itga3^tm1Son/Itga3^tm1Son; Tg(KRT5-cre)5132Jlj/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

immune system

skin inflammation ( J:145988 )

• inflammation occurs frequently around 3 to 4 months of age at the ears and around the eyes

integument

skin inflammation ( J:145988 )

• inflammation occurs frequently around 3 to 4 months of age at the ears and around the eyes

alopecia ( J:145988 )

• alopecia starts at 3 to 4 months after birth and progresses with age

blistering ( J:145988 )

• microblisters occur at the dermis-epidermis junction

thick skin ( J:145988 )

• epidermis is thickened around the ears, the eyes, and at sites of microblistering

Genotype
MGI:3836769

cn3

• Allelic Composition: Itga3^tm1Son/Itga3^tm1Son; Krt14^tm1(cre)Wbm/Krt14⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

homeostasis/metabolism

enhanced wound healing ( J:145988 )

• wound healing of the epidermis is accelerated

• about 90% of experimental wounds are closed after one week compared to about 60% in controls

• this enhanced wound healing is due to accelerated keratinocyte migration from sides of wound and not from increased proliferation

immune system

skin inflammation ( J:145988 )

• inflammation occurs frequently around 3 to 4 months of age at the ears and around the eyes

integument

skin inflammation ( J:145988 )

• inflammation occurs frequently around 3 to 4 months of age at the ears and around the eyes

alopecia ( J:145988 )

• alopecia starts at 3- to 4- months after birth and progresses with age

blistering ( J:145988 )

• microblisters occur at the dermis-epidermis junction

thick skin ( J:145988 )

• epidermis is thickened around the ears, the eyes, and at sites of microblistering

Genotype
MGI:3691146

cn4

• Allelic Composition: Itga3^tm1Son/Itga3^tm1Son; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: Not Specified

Glomerular basement membrane abnormalities and foot process effacement in kidneys of mildly affected Cd151^tm1Nki/Cd151^tm1Nki and Itga3^tm1Son/Itga3^tm1Son Tg(NPHS2-cre)295Lbh/0 mice

renal/urinary system

increased urine protein level ( J:114988 )

• exhibit massive proteinuria starting within the first week of age

albuminuria ( J:114988 )

podocyte foot process effacement ( J:114988 )

• complete effacement of podocyte foot processes in newborns

abnormal renal glomerulus basement membrane morphology ( J:114988 )

• glomerular basement membrane (GBM) is disorganized

• 6 week old mutants show widespread lamination and protrusions of the GBM

increased renal glomerulus basement membrane thickness ( J:114988 )

• abnormally thickened GBM with protrusions throughout the glomerulus

glomerulosclerosis ( J:114988 )

• kidneys contain partially sclerosed glomeruli

dilated proximal convoluted tubule ( J:114988 )

• dilated proximal tubules contain prominent protein casts

renal cast ( J:114988 )

• dilated proximal tubules contain prominent protein casts

pale kidney ( J:114988 )

• milky, discolored kidneys

homeostasis/metabolism

edema ( J:114988 )

• develop abdominal edema at 5-6 weeks of age

increased urine protein level ( J:114988 )

• exhibit massive proteinuria starting within the first week of age

albuminuria ( J:114988 )