All Phenotypes Gpbar1<tm1Ktan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gpbar1^tm1Ktan
targeted mutation 1, Kenichi Tanaka
MGI:3691111

Summary

2 genotypes

Allelic Composition	Gpbar1^tm1Ktan/Gpbar1^tm1Ktan
Genetic Background	involves: 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpbar1^tm1Ktan mutation (0 available); any Gpbar1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

• on a high fat diet (HF) from 9 weeks of age to 2 months, female mutants show a significant change in weight compared to wild-type from 12 weeks

homeostasis/metabolism

• level is increased 16% in male homozygotes compared to wild-type males

abnormal bile salt homeostasis ( J:114971 )

• total bile acid pool (liver/gall bladder/small intestine) is reduced by 25 and 21% in male and female homozygotes

adipose tissue

abnormal adipose tissue amount ( J:114971 )

• at 18 weeks of age, fat mass in females increased without change in lean mass

Allelic Composition	Gpbar1^tm1Ktan/Gpbar1⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6N