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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nit1tm1.1Hbn
targeted mutation 1, Kay Huebner
MGI:3691199
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nit1tm1.1Hbn/Nit1tm1.1Hbn involves: 129X1/SvJ * C57BL/6 MGI:3691214
ht2
 		Nit1tm1Hbn/Nit1tm1.1Hbn involves: 129X1/SvJ * C57BL/6 MGI:3691216


Genotype
MGI:3691214
hm1
Allelic
Composition		 Nit1tm1.1Hbn/Nit1tm1.1Hbn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nit1tm1.1Hbn mutation (0 available); any Nit1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:115052 )
• mutation does not affect embryogenesis, and growth and development are normal; mice did not develop spontaneous tumors during a year of observation

neoplasm
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice




Genotype
MGI:3691216
ht2
Allelic
Composition		 Nit1tm1Hbn/Nit1tm1.1Hbn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nit1tm1.1Hbn mutation (0 available); any Nit1 mutation (15 available)
Nit1tm1Hbn mutation (0 available); any Nit1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory