About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Gnrh1-cre)1Dlc
transgene insertion 1, Catherine Dulac
MGI:3691288
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Pomc-EGFP)1Low/0
Tg(Gnrh1-cre)1Dlc/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:5524047
cn2
 		Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA MGI:5524048
cn3
 		Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Tg(Pomc-EGFP)1Low/0 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA MGI:5524046
cn4
 		Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh
Tg(Gnrh1-cre)1Dlc/0 		involves: C57BL/6 * CBA MGI:5558863
cn5
 		Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh
Tg(Gnrh1-cre)1Dlc/0
Tg(Gnrh1-Kiss1r)#Aeh/0 		involves: C57BL/6 * CBA MGI:5558864


Genotype
MGI:5524047
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Pomc-EGFP)1Low/0
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small ovary ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
decreased uterus weight ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice

nervous system
decreased neuron number ( J:199640 )
• severe reduction in Pomc+ neurons

adipose tissue
increased abdominal adipose tissue amount ( J:199640 )
• increased visceral fat mass
• however, subcutaneous adipose weight is normal

endocrine/exocrine glands
small ovary ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice




Genotype
MGI:5524048
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron number ( J:199640 )
• Gnrh+ neurons in the medial preoptic area and posterior hypothalamus
ectopic neuron ( J:199640 )
• in the anterior olfactory nucleus




Genotype
MGI:5524046
cn3
Allelic
Composition		 Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Tg(Pomc-EGFP)1Low/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:199640 )
N
• mice exhibit normal uteri and testis weights

nervous system
decreased neuron number ( J:199640 )
• severe reduction in Pomc+ neurons in the medial preoptic area and posterior hypothalamus in male and female mice
• reduced Gnhr+ neurons in male and female mice

adipose tissue
increased white adipose tissue amount ( J:199640 )
• increased visceral fat mass weight in male and female mice but not as much as in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
• however, subcutaneous adipose weight is normal

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:199640 )
N
• mice exhibit normal estradiol levels




Genotype
MGI:5558863
cn4
Allelic
Composition		 Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1rtm1.1Aeh mutation (0 available); any Kiss1r mutation (21 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced gonadal size in Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh Tg(Gnrh1-cre)1Dlc mice is rescued by the Tg(Gnrh1-Kiss1r)#Aeh transgene

reproductive system

homeostasis/metabolism
decreased luteinizing hormone level ( J:206044 )
• in male mice with a failure to respond to kisspeptin treatment

endocrine/exocrine glands

cellular




Genotype
MGI:5558864
cn5
Allelic
Composition		 Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh
Tg(Gnrh1-cre)1Dlc/0
Tg(Gnrh1-Kiss1r)#Aeh/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1rtm1.1Aeh mutation (0 available); any Kiss1r mutation (21 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Gnrh1-Kiss1r)#Aeh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced gonadal size in Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh Tg(Gnrh1-cre)1Dlc mice is rescued by the Tg(Gnrh1-Kiss1r)#Aeh transgene

reproductive system
reproductive system phenotype ( J:206044 )
N
• female and male mice exhibit normal testes weight and mature sexually

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:206044 )
N
• mice exhibit normal follicle-stimulating hormone levels




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory