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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Gnrh1-cre)1Dlc
transgene insertion 1, Catherine Dulac
MGI:3691288
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Pomc-EGFP)1Low/0
Tg(Gnrh1-cre)1Dlc/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:5524047
cn2
 		Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA MGI:5524048
cn3
 		Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Tg(Pomc-EGFP)1Low/0 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA MGI:5524046
cn4
 		Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh
Tg(Gnrh1-cre)1Dlc/0 		involves: C57BL/6 * CBA MGI:5558863
cn5
 		Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh
Tg(Gnrh1-cre)1Dlc/0
Tg(Gnrh1-Kiss1r)#Aeh/0 		involves: C57BL/6 * CBA MGI:5558864


Genotype
MGI:5524047
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Pomc-EGFP)1Low/0
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small ovary ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
decreased uterus weight ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice

nervous system
decreased neuron number ( J:199640 )
• severe reduction in Pomc+ neurons

adipose tissue
increased abdominal adipose tissue amount ( J:199640 )
• increased visceral fat mass
• however, subcutaneous adipose weight is normal

endocrine/exocrine glands
small ovary ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice




Genotype
MGI:5524048
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron number ( J:199640 )
• Gnrh+ neurons in the medial preoptic area and posterior hypothalamus
ectopic neuron ( J:199640 )
• in the anterior olfactory nucleus




Genotype
MGI:5524046
cn3
Allelic
Composition		 Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Tg(Pomc-EGFP)1Low/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:199640 )
N
• mice exhibit normal uteri and testis weights

nervous system
decreased neuron number ( J:199640 )
• severe reduction in Pomc+ neurons in the medial preoptic area and posterior hypothalamus in male and female mice
• reduced Gnhr+ neurons in male and female mice

adipose tissue
increased white adipose tissue amount ( J:199640 )
• increased visceral fat mass weight in male and female mice but not as much as in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
• however, subcutaneous adipose weight is normal

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:199640 )
N
• mice exhibit normal estradiol levels




Genotype
MGI:5558863
cn4
Allelic
Composition		 Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1rtm1.1Aeh mutation (0 available); any Kiss1r mutation (21 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced gonadal size in Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh Tg(Gnrh1-cre)1Dlc mice is rescued by the Tg(Gnrh1-Kiss1r)#Aeh transgene

reproductive system

homeostasis/metabolism
decreased luteinizing hormone level ( J:206044 )
• in male mice with a failure to respond to kisspeptin treatment

endocrine/exocrine glands

cellular




Genotype
MGI:5558864
cn5
Allelic
Composition		 Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh
Tg(Gnrh1-cre)1Dlc/0
Tg(Gnrh1-Kiss1r)#Aeh/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1rtm1.1Aeh mutation (0 available); any Kiss1r mutation (21 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Gnrh1-Kiss1r)#Aeh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced gonadal size in Kiss1rtm1.1Aeh/Kiss1rtm1.1Aeh Tg(Gnrh1-cre)1Dlc mice is rescued by the Tg(Gnrh1-Kiss1r)#Aeh transgene

reproductive system
reproductive system phenotype ( J:206044 )
N
• female and male mice exhibit normal testes weight and mature sexually

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:206044 )
N
• mice exhibit normal follicle-stimulating hormone levels




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory