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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scn5atm1(SCN5A)Rdn
targeted mutation 1, Dan M Roden
MGI:3691483
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scn5atm1(SCN5A)Rdn/Scn5atm1(SCN5A)Rdn involves: 129S6/SvEvTac MGI:3692322
ht2
 		Scn5atm1(SCN5A)Rdn/Scn5atm3(SCN5A*)Rdn involves: 129S6/SvEvTac MGI:5445936


Genotype
MGI:3692322
hm1
Allelic
Composition		 Scn5atm1(SCN5A)Rdn/Scn5atm1(SCN5A)Rdn
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn5atm1(SCN5A)Rdn mutation (1 available); any Scn5a mutation (105 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:115269 )
• homozygotes are viable, exhibit no obvious morphological abnormalities and are fertile, and have normal sodium channel function as shown by electrocardiograms, ventricular myocyte action potentials, and ventricular myocyte sodium currents




Genotype
MGI:5445936
ht2
Allelic
Composition		 Scn5atm1(SCN5A)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn5atm1(SCN5A)Rdn mutation (1 available); any Scn5a mutation (105 available)
Scn5atm3(SCN5A*)Rdn mutation (1 available); any Scn5a mutation (105 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
dilated heart left ventricle ( J:189389 )
• intermediate at 12 weeks
decreased cardiac muscle contractility ( J:189389 )
• intermediate at 12 weeks
decreased heart rate ( J:189389 )
• intermediate at 3 weeks
prolonged P wave ( J:189389 )
• intermediate at 3 and 12 weeks
prolonged QRS complex duration ( J:189389 )
• intermediate at 3 weeks

muscle
decreased cardiac muscle contractility ( J:189389 )
• intermediate at 12 weeks

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1E DOID:0110433 OMIM:601154
 J:189389




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory