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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3catm1Jjz
targeted mutation 1, Jean J Zhao
MGI:3691486
Summary 4 genotypes


Genotype
MGI:5506907
cn1
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Pik3cbtm1Jjz/Pik3cbtm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3catm1Jjz Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (89 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:199362 )
N
• mutants do not develop hamartomas over a period of 300 days and epidermal thickness is normal at 8 weeks of age




Genotype
MGI:5506905
cn2
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (89 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
thick epidermis stratum basale ( J:199362 )
• expanded basal cell layers
skin lesions ( J:199362 )
• development of skin lesions is delayed and severity is reduced compared to single Pten mutants
thick skin ( J:199362 )
• skin is thickened at 8 weeks of age, but to a lesser extent than in single Pten mutants
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 121 days

neoplasm
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 121 days




Genotype
MGI:3805864
cn3
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:138565 )
• following cre-mediated recombination, mouse embryonic fibroblasts (MEFs) undergo reduced levels of immortalization upon exposure to HRas-G12V or EGFR-Del from feeder cells

neoplasm
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias




Genotype
MGI:6382534
cn4
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Tg(OPN1LW-cre)4Yzl/0
Genetic
Background		 involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Tg(OPN1LW-cre)4Yzl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina cone cell degeneration ( J:282245 )
• cone cell loss in 3 month old mice
• however, overall morphology and structural integrity of retinas is normal at 3 months of age
decreased b-wave amplitude ( J:282245 )
• photopic ERG b-wave recordings of cone photoreceptors are lower at 3 months of age
• however, scotopic ERG recordings of rod photoreceptors are normal at 3 months of age

nervous system
retina cone cell degeneration ( J:282245 )
• cone cell loss in 3 month old mice
• however, overall morphology and structural integrity of retinas is normal at 3 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory