Phenotypes associated with this allele

• Allele Symbol: Slc6a4^tm1(cre)Xz
• Allele Name: targeted mutation 1, Xiaoxi Zhuang
• Allele ID: MGI:3691577
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a4^tm1(cre)Xz/Slc6a4^tm1(cre)Xz	involves: 129S1/Sv * C57BL/6	MGI:4417856
ht2	Slc6a4^tm1(cre)Xz/Slc6a4^+	involves: 129S1/Sv * C57BL/6 * SJL	MGI:3691580
cn3	Slc18a2^tm1.1Bgir/Slc18a2^tm1.1Bgir Slc6a4^tm1(cre)Xz/Slc6a4^+	involves: 129S1/Sv * C57BL/6J	MGI:5497000

Genotype
MGI:4417856

hm1

• Allelic Composition: Slc6a4^tm1(cre)Xz/Slc6a4^tm1(cre)Xz
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:155633 )

• 75% of mice die with the first week after birth

cardiovascular system

cardiac fibrosis ( J:155633 )

• at E18.5, mice exhibit an increase in collagen accumulation in the myocardium and valvular and perivascular regions of the heart unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sudden infant death syndrome		DOID:9007	OMIM:272120	J:155633

Genotype
MGI:3691580

ht2

• Allelic Composition: Slc6a4^tm1(cre)Xz/Slc6a4⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:115426 )

• mice are viable and fertile

Genotype
MGI:5497000

cn3

• Allelic Composition: Slc18a2^tm1.1Bgir/Slc18a2^tm1.1Bgir; Slc6a4^tm1(cre)Xz/Slc6a4⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

mortality/aging

postnatal lethality, incomplete penetrance ( J:197966 )

• some mice die between P1 and P30

behavior/neurological

abnormal emotion/affect behavior ( J:197966 )

• in a tail suspension test, mice exhibit an increase in active defense behavior indicated by increased time spent struggling to escape and decreased immobilization compared with wild-type mice

• in response to aversive ultrasonic stimulus, mice exhibit a large increase in behavioral reactivity with less freezing compared with wild-type mice

• however, mice treated with pargyline exhibit normal flight responses in response to ultrasonic stimulus

decreased anxiety-related response ( J:197966 )

• in a novelty-suppressed feeding test, mice exhibit faster initiation of feeding compared with wild-type mice

decreased locomotor activity ( J:197966 )

• in an elevated plus maze

homeostasis/metabolism

abnormal catecholamine level ( J:197966 )

• decreased in the hippocampus but not the cortex or striatum

decreased serotonin level ( J:197966 )

• in the brain (cortex, striatum and brain stem) and blood

• mice treated with pargyline exhibit lower 5-HT levels compared with wild-type mice

• however, mice exhibit normal 5-HIAA brain levels and serotonin gut levels

nervous system

nervous system phenotype ( J:197966 )

N • 5-HT raphe neurons develop normally