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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rettm13.1Jmi
targeted mutation 13.1, Jeffrey Milbrandt
MGI:3691588
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rettm13.1Jmi/Rettm13.1Jmi involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3692550
cn2
 		Rettm13.1Jmi/Rettm13Jmi
Slc6a3tm1(cre)Xz/Slc6a3+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3692551


Genotype
MGI:3692550
hm1
Allelic
Composition		 Rettm13.1Jmi/Rettm13.1Jmi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm13.1Jmi mutation (1 available); any Ret mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:114682 )
N
• midbrain dopaminergic neurons develop normally
absent enteric neurons ( J:114682 )
• mice display intestinal aganglionosis

renal/urinary system
absent kidney ( J:114682 )
• renal agenesis occurs in homozygotes, identical to conventional Ret-null animals




Genotype
MGI:3692551
cn2
Allelic
Composition		 Rettm13.1Jmi/Rettm13Jmi
Slc6a3tm1(cre)Xz/Slc6a3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm13.1Jmi mutation (1 available); any Ret mutation (54 available)
Rettm13Jmi mutation (1 available); any Ret mutation (54 available)
Slc6a3tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased locomotor activity ( J:114682 )
• adults are modestly but significantly less active than heterozygous controls; total ambulations during a 1 hour observation session are lower in conditional null mice
• mice exhibit normal rearing behavior but travel less in the field periphery and make fewer entries into center compared to controls

nervous system
nervous system phenotype ( J:114682 )
N
• although Ret expression is lost, in adults the total cell counts and size of dopaminergic neurons, TH-positive fiber density in the striatum and nucleus accumbens, nigrostriatal and ventral tegmental area pathways, and levels of dopamine and its metabolites, are all similar to wild-type
• mice do not appear to have sensorimotor deficits with the modest decrease in locomotor activity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory