Analysis Tools
reproductive system
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• intermitochondrial cement is absent in mutant oocytes
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• chromatoid bodies, although present, are smaller and less organized in mutant spermatids than in wild-type
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• at 14 days after birth, apoptosis is increased in mutant spermatocytes compared to wild-type; elevated apoptosis is observed among spermatocytes and round spermatids in mutant testes 20 days after birth and continues to occur in adult testes
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small testis
(
J:115333
)
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• testes in adult males are much smaller than in wild-type males
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• cellular elongation and nuclear condensation of spermatids does not occur
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azoospermia
(
J:115333
)
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• mature spermatozoa are lacking
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• round spermatids show degeneration, such as vacuolization and intracellular degeneration
• chromatoid bodies, although present, are smaller and less organized in mutant spermatids than in wild-type
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• spermatocytes show degeneration, such as vacuolization and intracellular degeneration
• intermitochondrial cement is lacking in mutant spermatocytes although clusters of mitochondria form
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• differentiation of spermatocytes later than pachytene-diplotene stages is blocked in subset of seminiferous tubules, but in other tubules meiosis progresses further with haploid round spermatids being observed then stops
• 8 weeks after birth, about 20% of seminiferous tubules contain only spermatogonia and leptotene-zygotene spermatocytes, 65% contain up to pachytene-diplotene spermatocytes and 15% contain round spermatids
• cellular elongation and nuclear condensation of spermatids does not occur
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• mature spermatozoa are lacking
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endocrine/exocrine glands
small testis
(
J:115333
)
|
|
• testes in adult males are much smaller than in wild-type males
|
cellular
|
|
• intermitochondrial cement is absent in mutant oocytes
|
azoospermia
(
J:115333
)
|
|
• mature spermatozoa are lacking
|
|
• chromatoid bodies, although present, are smaller and less organized in mutant spermatids than in wild-type
|
|
|
• round spermatids show degeneration, such as vacuolization and intracellular degeneration
• chromatoid bodies, although present, are smaller and less organized in mutant spermatids than in wild-type
|
|
|
• spermatocytes show degeneration, such as vacuolization and intracellular degeneration
• intermitochondrial cement is lacking in mutant spermatocytes although clusters of mitochondria form
|
|
|
• at 14 days after birth, apoptosis is increased in mutant spermatocytes compared to wild-type; elevated apoptosis is observed among spermatocytes and round spermatids in mutant testes 20 days after birth and continues to occur in adult testes
|
