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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcptm1Ysas
targeted mutation 1, Yoshiki Sasai
MGI:3691856
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcptm1Ysas/Kcptm1Ysas involves: C57BL/6 * CBA MGI:3692273
cx2
 		Bmpertm1Ysas/Bmpertm1Ysas
Kcptm1Ysas/Kcptm1Ysas 		involves: C57BL/6 * CBA MGI:3692277
cx3
 		Bmpertm1Ysas/Bmpertm1Ysas
Kcptm1Ysas/Kcp+ 		involves: C57BL/6 * CBA MGI:3692281


Genotype
MGI:3692273
hm1
Allelic
Composition		 Kcptm1Ysas/Kcptm1Ysas
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcptm1Ysas mutation (1 available); any Kcp mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:115338 )
• homozygotes are viable and fertile and exhibit no gross structural defects, including in kidney formation




Genotype
MGI:3692277
cx2
Allelic
Composition		 Bmpertm1Ysas/Bmpertm1Ysas
Kcptm1Ysas/Kcptm1Ysas
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpertm1Ysas mutation (1 available); any Bmper mutation (47 available)
Kcptm1Ysas mutation (1 available); any Kcp mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased renal glomerulus number ( J:115338 )
• exhibit a further reduction in the glomerulus number compared to single Bmper homozygotes
abnormal kidney corticomedullary boundary morphology ( J:115338 )
• exhibit a strong disorganization of the cortex-medullar arrangement with no clear border in between
small kidney ( J:115338 )
• exhibit a further reduction in kidney size than seen in single Bmper homozygotes

skeleton
abnormal skeleton morphology ( J:115338 )
• exhibit skeletal phenotypes similar to that seen in single homozygous Bmper mutants that are not enhanced by the deletion of Crim2




Genotype
MGI:3692281
cx3
Allelic
Composition		 Bmpertm1Ysas/Bmpertm1Ysas
Kcptm1Ysas/Kcp+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpertm1Ysas mutation (1 available); any Bmper mutation (47 available)
Kcptm1Ysas mutation (1 available); any Kcp mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased renal glomerulus number ( J:115338 )
• exhibit a further reduction in the glomerulus number compared to single Bmper homozygotes
abnormal kidney corticomedullary boundary morphology ( J:115338 )
• exhibit a strong disorganization of the cortex-medullar arrangement with no clear border in between
small kidney ( J:115338 )
• exhibit a further reduction in kidney size than seen in single Bmper homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory