Analysis Tools|
Allele Symbol Allele Name Allele ID |
Six2tm1Gco targeted mutation 1, Guillermo Oliver MGI:3691857 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12.5 dpc, there is evidence of nephron formation; embryos show ectopic renal vesicle formation with these structures appearing on the dorsal side of the kidneys as well as on the ventral, while they are confined to the ventral (medullary) side in normal controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12.5 dpc, ectopic renal vesicles form on the dorsal (cortical) side of kidneys
• reduction of Pax2+ve cap mesenchyme is observed at 12.5 dpc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die soon after birth
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• exhibit an increase in cell apoptosis in the metanephric mesenchyme and stroma of the E11.5 kidney, with no changes in apoptosis at E10.5 or E12.5, but increases from E14.5 to E17.5
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• exhibit a reduction in the reserve of metanephric mesenchyme in the cortex, indicating depletion of the mesenchymal progenitor/stem cell population
• stromal population in the kidney is reduced in size at E12.5
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• exhibit premature and ectopic differentiation of mesenchymal cells into epithelia and depletion of the progenitor cell population within the metanephric mesenchyme
• formation of epithelial vesicles is not observed at E11.5 in the developing kidney, and instead the kidney displays ectopic and premature mesenchymal-epithelial translation that leads to the formation of precocious epithelial renal vesicles surrounding the ureteric bud
• at E12.5, show an absence of the condensing metanephric mesenchyme
• at E14.5, the kidney shows abnormal, unorganized masses of nephric epithelia and lacks condensing mesenchyme in the peripheral nephrogenic zone and ureteric bud branches throughout the kidney
• kidney explants develop glomeruli, however only a few connections between the nephric structures and the ureteric bud are seen
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• kidneys are about 50% and 65% smaller at E14.5 and E16.5, respectively
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• failure to renew the mesenchymal cells results in severe renal hypoplasia
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• kidneys exhibit premature and arrested nephrogenesis
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• kidneys develop more nephrons than controls at E12.5 due to premature nephrogenesis
• however, later on, the number of nephrons is less than in wild-type
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• at E12.5, the ureteric bud has not yet branched beyond the initial T stage of development
• at E14.5, the kidney lacks ureteric bud branches throughout the kidney
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12.5 dpc, the amount of cap mesenchyme is greatly reduced
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• no renal vesicle formation is observed at 12.5 dpc
• ingrowth of the ureteric bud is delayed compared to controls at 11.5 dpc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no renal vesicle formation is observed at 12.5 dpc
• ingrowth of the ureteric bud is delayed compared to Six2- or Wnt9b-null animals
• significant reduction of Pax2+ve cap mesenchyme is observed at 12.5 dpc; reduction is more severe than in Wnt9b single null mice
• renal vesicle-forming progenitors are depleted in the cap mesenchyme
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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