Phenotypes associated with this allele

• Allele Symbol: Or8a1b^tm6Mom
• Allele Name: targeted mutation 6, Peter Mombaerts
• Allele ID: MGI:3692202
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hcn1^tm2Kndl/Hcn1^tm2Kndl Or8a1b^tm6Mom/Or8a1b^tm6Mom	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:4849470
cx2	Or8a1^tm2Mom/Or8a1^+ Or8a1b^tm6Mom/Or8a1b^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3694130
cx3	Or8a1^tm25Mom/? Or8a1b^tm6Mom/? Pcdha^tm3Tyag/Pcdha^tm3Tyag	involves: 129P2/OlaHsd * C57BL/6	MGI:3799116

Genotype
MGI:4849470

cx1

• Allelic Composition: Hcn1^tm2Kndl/Hcn1^tm2Kndl; Or8a1b^tm6Mom/Or8a1b^tm6Mom
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:166733 )

• shortened neurite length in primary cultures of olfactory sensory neurons

abnormal olfactory bulb morphology ( J:166733 )

• although OLFR160 glomeruli have a normal position, the dorsomedial OLFR1507 glomeruli are abnormally positioned caudal rather than rostral to the first accessory olfactory bulb

abnormal olfactory bulb development ( J:166733 )

• at embryonic day 17 protoglomeruli formation is delayed, at 4 days of age glomeruli can be identified but are poorly formed and lack discrete boundaries, and in the adult the glomeruli remain irregularly shaped and not well circumscribed

abnormal olfactory bulb layer morphology ( J:166733 )

• the division of the inner and outer nerve layers of the olfactory bulb is perturbed

abnormal olfactory bulb glomerular layer morphology ( J:166733 )

• although the number of glomeruli and their regional distribution are normal, the glomeruli from the dorsal olfactory bulb are larger than normal and more glomeruli are radially stacked resutling in abnormal lamination

abnormal olfactory bulb outer nerve layer morphology ( J:166733 )

craniofacial

abnormal olfactory sensory neuron morphology ( J:166733 )

• shortened neurite length in primary cultures of olfactory sensory neurons

respiratory system

abnormal olfactory sensory neuron morphology ( J:166733 )

• shortened neurite length in primary cultures of olfactory sensory neurons

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:166733 )

• shortened neurite length in primary cultures of olfactory sensory neurons

growth/size/body

abnormal olfactory sensory neuron morphology ( J:166733 )

• shortened neurite length in primary cultures of olfactory sensory neurons

Genotype
MGI:3694130

cx2

• Allelic Composition: Or8a1^tm2Mom/Or8a1⁺; Or8a1b^tm6Mom/Or8a1b⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal olfactory bulb morphology ( J:90716 )

abnormal olfactory neuron innervation pattern ( J:90716 )

• Olfr151 and Olfr160 axons only intermingle to a small extent; atypical glomeruli are formed in which some co-mingling of Olfr151^tm2Momaxons with both Olfr151 and Olfr160 axons occurs, but Olfr151^tm2Momaxons are shared between glomeruli

Genotype
MGI:3799116

cx3

• Allelic Composition: Or8a1^tm25Mom/?; Or8a1b^tm6Mom/?; Pcdha^tm3Tyag/Pcdha^tm3Tyag
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal olfactory bulb morphology ( J:136920 )

• labeled axons form multiple glomeruli but none of the olfactory sensory neurons express both GFP and lacZ indicating olfactory receptor gene choice is not perturbed