Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Tnnt2*R92Q)3Lnwd
• Allele Name: transgene insertion 3, Leslie A Leinwand
• Allele ID: MGI:3692451
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Tnnt2*R92Q)3Lnwd/0	involves: C57BL/6	MGI:5755256

Genotype
MGI:5755256

tg1

• Allelic Composition: Tg(Myh6-Tnnt2*R92Q)3Lnwd/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

perivascular fibrosis ( J:56911 )

abnormal myocardial fiber morphology ( J:56911 )

• evidence of myocyte necrosis and inflammatory change

• myocytes exhibit lipid deposition and increased number of mitochondria with evidence of mitochondrial degeneration

• frequent apoptotic nuclei are seen in myocytes

myocardial fiber degeneration ( J:56911 )

• frequent foci of degenerating cardiac myocytes

myocardial fiber disarray ( J:56911 )

• myocellular disarray

abnormal heart atrium morphology ( J:56911 )

• progressive atrial hypertrophy

cardiac hypertrophy ( J:56911 )

• progressive atrial hypertrophy; increase in atrial mass is apparent at 4 weeks of age

• both left and right atria are affected, although a left atrial predominance develops with increasing age

• hearts exhibit expression of hypertrophic markers

abnormal heart ventricle morphology ( J:56911 )

• ventricular mass decreases by about 18%

decreased heart left ventricle size ( J:56911 )

cardiac interstitial fibrosis ( J:56911 )

• hearts show extensive areas of myocardial fibrosis

heart inflammation ( J:56911 )

• evidence of inflammatory change

growth/size/body

cardiac hypertrophy ( J:56911 )

• progressive atrial hypertrophy; increase in atrial mass is apparent at 4 weeks of age

• both left and right atria are affected, although a left atrial predominance develops with increasing age

• hearts exhibit expression of hypertrophic markers

immune system

heart inflammation ( J:56911 )

• evidence of inflammatory change

muscle

abnormal myocardial fiber morphology ( J:56911 )

• evidence of myocyte necrosis and inflammatory change

• myocytes exhibit lipid deposition and increased number of mitochondria with evidence of mitochondrial degeneration

• frequent apoptotic nuclei are seen in myocytes

myocardial fiber degeneration ( J:56911 )

• frequent foci of degenerating cardiac myocytes

myocardial fiber disarray ( J:56911 )

• myocellular disarray

abnormal sarcomere morphology ( J:56911 )

• sarcomere lengths are shorter in left ventricular myocytes

cellular

cardiac interstitial fibrosis ( J:56911 )

• hearts show extensive areas of myocardial fibrosis