Phenotypes associated with this allele

• Allele Symbol: Map3k12^tm1Shir
• Allele Name: targeted mutation 1, Syu-ichi Hirai
• Allele ID: MGI:3692456
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k12^tm1Shir/Map3k12^tm1Shir	B6.Cg-Mapk12^tm1Shir	MGI:3693127

Genotype
MGI:3693127

hm1

• Allelic Composition: Map3k12^tm1Shir/Map3k12^tm1Shir
• Genetic Background: B6.Cg-Mapk12^tm1Shir

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:115575 )

• homozygotes survive embryonic period but die perinatally (no mutants survive to weaning)

nervous system

decreased neuronal migration ( J:115575 )

• at E19, cortical neurons are more dispersed in cortical plate and fewer nuclei (39%) are located in the outermost layer of cortical plate compared to controls (57%); significant reductions are also found in dorsolateral and lateral cortices

• in locomotion-type cell migration, a reduction in fast migrating subcortical and cortical plate neurons (SC-CP) is observed; acceleration of radial migration of neurons in subplate region is decreased in mutant slices compared to control slices

abnormal brain morphology ( J:115575 )

abnormal brain white matter morphology ( J:115575 )

decreased corpus callosum size ( J:115575 )

• corpus callosum is reduced in size

abnormal anterior commissure morphology ( J:115575 )

abnormal anterior commissure pars anterior morphology ( J:115575 )

• anterior part of anterior commissure is barely detectable

abnormal anterior commissure pars posterior morphology ( J:115575 )

• posterior part of anterior commissure is reduced in size

abnormal brain internal capsule morphology ( J:115575 )

• fibers of internal capsule are reduced in number

abnormal cingulum morphology ( J:115575 )

• fibers of cingulum are reduced in number

abnormal cerebral cortex morphology ( J:115575 )

• bundle of ventrally extended axons that project ventrolaterally to internal capsule in E19 control brains, is diminished in mutant brain

• layer-specific cell density less distinct in mutants at E19; layered structure is partially disrupted

abnormal olfactory bulb morphology ( J:115575 )

• layer structure is intact, but glomerular layer thickness is reduced compared to controls

abnormal olfactory tract morphology ( J:115575 )

• lateral olfactory tract is reduced in thickness

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:115575 )

• c-Jun (JNK) kinase activity is reduced in brains of mutants compared to control

cellular

decreased neuronal migration ( J:115575 )

• at E19, cortical neurons are more dispersed in cortical plate and fewer nuclei (39%) are located in the outermost layer of cortical plate compared to controls (57%); significant reductions are also found in dorsolateral and lateral cortices

• in locomotion-type cell migration, a reduction in fast migrating subcortical and cortical plate neurons (SC-CP) is observed; acceleration of radial migration of neurons in subplate region is decreased in mutant slices compared to control slices