All Phenotypes Tg(Sim1-cre)2Lowl MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Sim1-cre)2Lowl
transgene insertion 2, Bradford B Lowell
MGI:3692527

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mc4r^tm1Lowl/Mc4r^tm1Lowl Tg(Sim1-cre)2Lowl/0	involves: 129S4/SvJae * C57BL/6J * FVB	MGI:3692536

Allelic Composition	Mc4r^tm1Lowl/Mc4r^tm1Lowl Tg(Sim1-cre)2Lowl/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm1Lowl mutation (2 available); any Mc4r mutation (48 available)
Tg(Sim1-cre)2Lowl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:115192 )

• mice expressing the transgene only in the posterior hypothalamus (PH) and having reactivated Mc4r in that region show no amelioration of obesity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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