Phenotypes associated with this allele

• Allele Symbol: Igh^tm1Kplm
• Allele Name: targeted mutation 1, Kong-Peng Lam
• Allele ID: MGI:3692558
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh^tm1Kplm/Igh^+	involves: A/WySnJ * BALB/c	MGI:3692976
ht2	Igh^tm1Kplm/Igh^+	Not Specified	MGI:3693005
ht3	Igh^tm1Kplm/Igh^tm4Cgn	involves: 129P2/OlaHsd	MGI:3693008
ht4	Igh^tm1Kplm/Igh^tm3Cgn	involves: C57BL/6	MGI:3693007
cx5	Igh^tm1Kplm/Igh^tm4Cgn Tg(Igk-V4CH27)1-2Shc/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3693009
cx6	Igh^tm1Kplm/Igh^+ Tg(Igk-V4CH27)1-2Shc/0	involves: C57BL/6 * SJL	MGI:3693010

Genotype
MGI:3692976

ht1

• Allelic Composition: Igh^tm1Kplm/Igh⁺
• Genetic Background: involves: A/WySnJ * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B-1 B cell morphology ( J:115788 )

• Tnfsf13b treatment does not stimulate proliferation of activated B-1 cells in culture

• expression of CD21/CD35 on B-1 cells from mutants is decreased compared to wild-type

immune system

abnormal B-1 B cell morphology ( J:115788 )

• Tnfsf13b treatment does not stimulate proliferation of activated B-1 cells in culture

• expression of CD21/CD35 on B-1 cells from mutants is decreased compared to wild-type

Genotype
MGI:3693005

ht2

• Allelic Composition: Igh^tm1Kplm/Igh⁺
• Genetic Background: Not Specified

hematopoietic system

abnormal B cell differentiation ( J:115292 )

• mice produce predominantly B-1 cells which express intermediate levels of CD5, low levels of B220 and IgD, and no detectable CD23

increased B cell number ( J:115292 )

• in 2-4 month old mice, B cell number in the spleen is increased 2-fold and 20-fold in peritoneal cavity compared to wild-type

immune system

abnormal B cell differentiation ( J:115292 )

• mice produce predominantly B-1 cells which express intermediate levels of CD5, low levels of B220 and IgD, and no detectable CD23

increased B cell number ( J:115292 )

• in 2-4 month old mice, B cell number in the spleen is increased 2-fold and 20-fold in peritoneal cavity compared to wild-type

Genotype
MGI:3693008

ht3

• Allelic Composition: Igh^tm1Kplm/Igh^tm4Cgn
• Genetic Background: involves: 129P2/OlaHsd

hematopoietic system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, B cells in these mice express high levels of B220 and IgD, and the majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells

abnormal B cell number ( J:115292 )

• splenic B cell number is similar to that found in wild-type and single Igh^tm3Cgn or Igh^tm4Cgn mutants, but peritoneal B cell number is increased, similar to Igh^tm1Kplm mutants

abnormal B-1 B cell morphology ( J:115292 )

• B cells expressing only Igh^tm1Kplm (indicating loss of the Igh^tm4Cgn allele) are phenotypically B-1 cells

immune system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, B cells in these mice express high levels of B220 and IgD, and the majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells

abnormal B cell number ( J:115292 )

• splenic B cell number is similar to that found in wild-type and single Igh^tm3Cgn or Igh^tm4Cgn mutants, but peritoneal B cell number is increased, similar to Igh^tm1Kplm mutants

abnormal B-1 B cell morphology ( J:115292 )

• B cells expressing only Igh^tm1Kplm (indicating loss of the Igh^tm4Cgn allele) are phenotypically B-1 cells

Genotype
MGI:3693007

ht4

• Allelic Composition: Igh^tm1Kplm/Igh^tm3Cgn
• Genetic Background: involves: C57BL/6

hematopoietic system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells

abnormal B cell number ( J:115292 )

• in 2-4 month old mice, splenic B cell number is similar to that found in wild-type and single Igh^tm3Cgn or Igh^tm4Cgnmutants, but peritoneal B cell number is increased, similar to Igh^tm1Kplm mutants

immune system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells

abnormal B cell number ( J:115292 )

• in 2-4 month old mice, splenic B cell number is similar to that found in wild-type and single Igh^tm3Cgn or Igh^tm4Cgnmutants, but peritoneal B cell number is increased, similar to Igh^tm1Kplm mutants

Genotype
MGI:3693009

cx5

• Allelic Composition: Igh^tm1Kplm/Igh^tm4Cgn; Tg(Igk-V4CH27)1-2Shc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

hematopoietic system

increased B cell number ( J:115292 )

• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Igh^tm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

immune system

increased B cell number ( J:115292 )

• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Igh^tm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

Genotype
MGI:3693010

cx6

• Allelic Composition: Igh^tm1Kplm/Igh⁺; Tg(Igk-V4CH27)1-2Shc/0
• Genetic Background: involves: C57BL/6 * SJL

hematopoietic system

increased B cell number ( J:115292 )

• mice have 2-fold more splenic B cells than Igh^tm1Kplm mutants and 8-fold more cells than Tg(Igk-V4CH27)1-2Shc or Igh^tm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

immune system

increased B cell number ( J:115292 )

• mice have 2-fold more splenic B cells than Igh^tm1Kplm mutants and 8-fold more cells than Tg(Igk-V4CH27)1-2Shc or Igh^tm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants