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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Tnnt2)191Lnwd
transgene insertion 191, Leslie A Leinwand
MGI:3692603
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Tnnt2)191Lnwd/0 involves: C57BL/6 MGI:3719611


Genotype
MGI:3719611
tg1
Allelic
Composition
Tg(Myh6-Tnnt2)191Lnwd/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no hemizygous male that serves as a stud survived more than 13 months

cardiovascular system
• neonatal and adult hearts show myocellular disorganization and degeneration
• exhibit about 8-10% fewer myocytes than controls
• mean length and midpoint width of quiescent ventricular cardiac myocytes are 15 and 13% smaller, respectively, than in controls and mean myocyte area is decreased by 17%
• neonatal and adult hearts show myocellular degeneration
• neonatal and adult hearts show myocellular disorganization
• exhibit atrial wall thickening
• exhibit early dilatation of the atria
• heart weight to body weight ratio shows an 18-27% decrease in heart mass at 4-5 months of age
• altering the physiologic load on the heart shows some impairment in contractility
• at a baseline workload, hearts exhibit a 25% decrease in the maximal rate of relaxation
• hearts show a moderately good correlation of +dP/dT to increased work, however the slope of the Starling curve is severely decreased during relaxation suggesting that hearts cannot respond to an increased work load by shortening their relaxation time
• isolated adult cardiac myocytes and hypersensitive to calcium; addition of calcium led to immediate cellular hypercontracture and death

muscle
• neonatal and adult hearts show myocellular disorganization and degeneration
• exhibit about 8-10% fewer myocytes than controls
• mean length and midpoint width of quiescent ventricular cardiac myocytes are 15 and 13% smaller, respectively, than in controls and mean myocyte area is decreased by 17%
• neonatal and adult hearts show myocellular degeneration
• neonatal and adult hearts show myocellular disorganization
• altering the physiologic load on the heart shows some impairment in contractility
• at a baseline workload, hearts exhibit a 25% decrease in the maximal rate of relaxation
• hearts show a moderately good correlation of +dP/dT to increased work, however the slope of the Starling curve is severely decreased during relaxation suggesting that hearts cannot respond to an increased work load by shortening their relaxation time

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 2 DOID:0110308 OMIM:115195
J:48301





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory