Phenotypes associated with this allele

• Allele Symbol: Gpbar1^tm1Gvas
• Allele Name: targeted mutation 1, Galya Vassileva
• Allele ID: MGI:3692767
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpbar1^tm1Gvas/Gpbar1^tm1Gvas	involves: 129S1/SvImJ * C57BL/6	MGI:3696949

Genotype
MGI:3696949

hm1

• Allelic Composition: Gpbar1^tm1Gvas/Gpbar1^tm1Gvas
• Genetic Background: involves: 129S1/SvImJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:115877 )

• negative feedback of cholesterol conversion to bile acid is altered compared to wild-type; hepatic mRNA levels of genes involved are higher than in wild-type

liver/biliary system

liver/biliary system phenotype ( J:115877 )

N • on a normal diet, mice do not show any obvious abnormalities

abnormal bile duct development ( J:115877 )

• mutants show less bile duct hyperplasia than conrols

abnormal gallbladder morphology ( J:115877 )

• in contrast to control gall bladders which contain thick layers of mucus and aggregated liquid cholesterol crystals, mutant gall bladders are clear or form small crystals when fed a lithogenic diet

gallstones ( J:115877 )

• mice fed a lithogenic diet for 8 weeks do not develop gallstones, while 54% of wild-type mice have gallstones

abnormal bile composition ( J:115877 )

• mutants have lower bile cholesterol saturation indices (CSI) than wild-type on lithogenic diet; phospholipids levels are significantly higher (43.5 umol/ml vs 32 umol/ml) on a lithogenic diet

endocrine/exocrine glands

abnormal bile duct development ( J:115877 )

• mutants show less bile duct hyperplasia than conrols

abnormal gallbladder morphology ( J:115877 )

• in contrast to control gall bladders which contain thick layers of mucus and aggregated liquid cholesterol crystals, mutant gall bladders are clear or form small crystals when fed a lithogenic diet