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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stx2repro34
reproductive mutation 34, JAX Reproductive Mutagenesis Program
MGI:3692880
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stx2repro34/Stx2repro34 involves: C3HeB/FeJ * C57BL/6J MGI:3692885


Genotype
MGI:3692885
hm1
Allelic
Composition		 Stx2repro34/Stx2repro34
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx2repro34 mutation (0 available); any Stx2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:92463 , J:136575 )
• no epididymal sperm (J:92463)
• instead of sperm only multinucleated giant cells are observed in the seminiferous tubules (J:136575)
multinucleated giant male germ cells ( J:136575 )
• instead of sperm only multinucleated giant cells are observed in the seminiferous tubules
decreased seminal vesicle weight ( J:92463 )
• low seminal vesicle weight
small testis ( J:136575 )
• testes are less than one quarter normal size
decreased testis weight ( J:92463 )
• very low testis weight
arrest of spermatogenesis ( J:136575 )
• spermatogenesis is arrested in the transition from spermatocyte to spermatids
arrest of male meiosis ( J:92463 , J:136575 )
• accumulation of meiotic division phase spermatocytes and degenerating round spermatids present in multinucleated cell bodies (J:92463)
• sperm cells fail to complete meiosis (J:136575)
male infertility ( J:92463 , J:136575 )
(J:92463)
(J:136575)

cellular
azoospermia ( J:92463 , J:136575 )
• no epididymal sperm (J:92463)
• instead of sperm only multinucleated giant cells are observed in the seminiferous tubules (J:136575)
multinucleated giant male germ cells ( J:136575 )
• instead of sperm only multinucleated giant cells are observed in the seminiferous tubules
arrest of male meiosis ( J:92463 , J:136575 )
• accumulation of meiotic division phase spermatocytes and degenerating round spermatids present in multinucleated cell bodies (J:92463)
• sperm cells fail to complete meiosis (J:136575)

endocrine/exocrine glands
decreased seminal vesicle weight ( J:92463 )
• low seminal vesicle weight
small testis ( J:136575 )
• testes are less than one quarter normal size
decreased testis weight ( J:92463 )
• very low testis weight




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory