Phenotypes associated with this allele

• Allele Symbol: Ercc1^tm2Dwm
• Allele Name: targeted mutation 2, David W Melton
• Allele ID: MGI:3692923
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ercc1^tm1Dwm/Ercc1^tm2Dwm Hr^hr/Hr^hr Tg(KRT5-cre)5132Jlj/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1	MGI:3696991

Genotype
MGI:3696991

cn1

• Allelic Composition: Ercc1^tm1Dwm/Ercc1^tm2Dwm; Hr^hr/Hr^hr; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:115849 )

• mice with a maternally inherited cre transgene die before weaning

• however, mice with a paternally inherited cre transgene are viable

neoplasm

increased incidence of tumors by UV-induction ( J:115849 )

• mice with a paternally inherited cre transgene develop tumors following chronic exposure to 125 J/m² UVB unlike control mice

• tumors appear earlier and grow faster in mice with a paternally inherited cre transgene compared to control mice receiving a 16-fold higher dose of UVB

• the cumulative UVB EC50 for tumor development is 3.75 kJ/m² in mice with a paternally inherited cre transgene compared to 140 kJ/m²control mice

growth/size/body

decreased birth body size ( J:115849 )

• mice with a maternally inherited cre transgene are severely runted at birth

liver/biliary system

abnormal hepatocyte morphology ( J:115849 )

• mice with a maternally inherited cre transgene develop premature polyploidy in hepatocytes

integument

increased sensitivity to skin irradiation ( J:115849 )

• the minimal erythemal dose of UVB is 40 J/m² in mice with a paternally inherited cre transgene compared to 900 J/m² in controls

• in mice with a paternally inherited cre transgene sensitivity to UVB induced changes in the epidermis (hyperplasia, hypertrophy, hypergranulosis, and hyperkeratosis) are increased