Phenotypes associated with this allele

• Allele Symbol: Nkx2-9^tm1Jlck
• Allele Name: targeted mutation 1, Joseph Locker
• Allele ID: MGI:3692933
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx2-9^tm1Jlck/Nkx2-9^tm1Jlck	involves: 129/Sv * C57BL/6 * SJL	MGI:3696574

Genotype
MGI:3696574

hm1

• Allelic Composition: Nkx2-9^tm1Jlck/Nkx2-9^tm1Jlck
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

increased lung tumor incidence ( J:115581 )

• 71% mutants 18 to 22 months of age develop spontaneous lung cancer compared to 25% of wild-type

increased lung adenoma incidence ( J:115581 )

• bronchial adenoma in aged mice

abnormal respiratory epithelium morphology ( J:115581 )

• tracheobronchial hyperplasia

• tracheobronchial epithelium is taller and more crowded with greater numbers of proliferating cells

abnormal bronchus epithelium morphology ( J:115581 )

• bronchial cell proliferation is increased in neonates

• proximal bronchi show irregular thickening and discrete dysplastic lesions

• in dysplastic lesions, the epithelium is thickened to 5 or more layers and the cells lose their normal basement membrane-luminal polarity

• bronchial epithelium progressively becomes more irregular throughout and shows frequent dysplastic lesions as mutants age

bronchial epithelial hyperplasia ( J:115581 )

• bronchial epithelial hyperplasia from birth, eventually leading to dysplasia in large airways

neoplasm

increased squamous cell carcinoma incidence ( J:115581 )

• poorly differentiated squamous carcinoma that is contiguous with dysplastic bronchial/bronchiolar epithelium and invades into veins

increased lung tumor incidence ( J:115581 )

• 71% mutants 18 to 22 months of age develop spontaneous lung cancer compared to 25% of wild-type

increased lung adenoma incidence ( J:115581 )

• bronchial adenoma in aged mice

nervous system

abnormal motor neuron innervation pattern ( J:182736 )

• spinal accessory motor neurons fail to exit the spinal cord and inappropriately assemble into an ectopic spinal accessory nerve

abnormal accessory nerve morphology ( J:182736 )

• spinal accessory motor neurons fail to exit the spinal cord and inappropriately assemble into an ectopic spinal accessory nerve

• spinal accessory motor neuron axons form disorganized nerve fascicles along the A-P axis of the spinal cord