Phenotypes associated with this allele

• Allele Symbol: Omp^tm4(cre)Mom
• Allele Name: targeted mutation 4, Peter Mombaerts
• Allele ID: MGI:3692980
• Summary: 11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ebf2^tm3(Zfp423*)Reed/Ebf2^+ Omp^tm4(cre)Mom/Omp^+	involves: 129 * 129P2/OlaHsd * C57BL/10J	MGI:5461575
cn2	Ebf2^tm2(Zfp423)Reed/Ebf2^+ Omp^tm4(cre)Mom/Omp^+	involves: 129 * 129P2/OlaHsd * C57BL/10J	MGI:5461577
cn3	Ebf2^tm2(Zfp423)Reed/Ebf2^+ Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd	MGI:3714638
cn4	Slc24a4^tm1.2Hazh/Slc24a4^tm1.2Hazh Omp^tm4(cre)Mom/Omp^tm4(cre)Mom	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5306367
cn5	Slc24a4^tm1.2Hazh/Slc24a4^tm1.2Hazh Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5306368
cn6	Gng13^tm1Liqh/Gng13^tm1Liqh Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:5517417
cn7	Cfap69^tm1c(KOMP)Wtsi/Cfap69^tm1c(KOMP)Wtsi Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:5912380
cn8	Ano9^em1Uoh/Ano9^em1Uoh Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd * C57BL/6	MGI:7581989
cn9	Omp^tm4(cre)Mom/Omp^+ Ric8b^tm1c(EUCOMM)Hmgu/Ric8b^tm1c(EUCOMM)Hmgu	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL	MGI:6119583
cn10	Omp^tm4(cre)Mom/Omp^+ Gucy1b2^tm3Mom Ift88^tm1Bky/Gucy1b2^tm3Mom Ift88^tm1Bky	involves: 129P2/OlaHsd * C57BL/6J	MGI:6725130
cn11	Gnao1^tm4Lbi/Gnao1^tm4Lbi Omp^tm4(cre)Mom/?	involves: 129P2/OlaHsd * C57BL/6J	MGI:6379998

Genotype
MGI:5461575

cn1

• Allelic Composition: Ebf2^{tm3(Zfp423*)Reed}/Ebf2⁺; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:190934 )

N • development of olfactory sensory neurons is similar to controls

Genotype
MGI:5461577

cn2

• Allelic Composition: Ebf2^{tm2(Zfp423)Reed}/Ebf2⁺; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

nervous system

impaired neuron differentiation ( J:190934 )

• impaired olfactory sensory neuron differentiation

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

taste/olfaction

abnormal olfactory epithelium morphology ( J:190934 )

• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

cellular

impaired neuron differentiation ( J:190934 )

• impaired olfactory sensory neuron differentiation

craniofacial

abnormal olfactory epithelium morphology ( J:190934 )

• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

respiratory system

abnormal olfactory epithelium morphology ( J:190934 )

• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

growth/size/body

abnormal olfactory epithelium morphology ( J:190934 )

• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

Genotype
MGI:3714638

cn3

• Allelic Composition: Ebf2^{tm2(Zfp423)Reed}/Ebf2⁺; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

Genotype
MGI:5306367

cn4

• Allelic Composition: Slc24a4^tm1.2Hazh/Slc24a4^tm1.2Hazh; Omp^tm4(cre)Mom/Omp^tm4(cre)Mom
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

growth/size/body

decreased body weight ( J:180325 )

• extreme

Genotype
MGI:5306368

cn5

• Allelic Composition: Slc24a4^tm1.2Hazh/Slc24a4^tm1.2Hazh; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

taste/olfaction

abnormal olfactory system physiology ( J:180325 )

• olfactory sensory neurons exhibit prolonged termination compared with control cells

impaired olfaction ( J:180325 )

• mice exhibit reduced ability to locate odors, as indicated by decreased body weight at weaning, compared with control mice

• mice exhibit impaired ability to find a buried pellet compared with control mice

• however, mice normally locate a visible pellet

nervous system

abnormal sensory neuron physiology ( J:180325 )

• olfactory sensory neurons exhibit prolonged termination compared with control cells

growth/size/body

decreased body weight ( J:180325 )

• at weaning likely due to impaired olfaction

Genotype
MGI:5517417

cn6

• Allelic Composition: Gng13^tm1Liqh/Gng13^tm1Liqh; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

mortality/aging

decreased survivor rate ( J:197147 )

• although mice are grossly normal, those born into litters of 7 or more display compromised survival

taste/olfaction

abnormal olfactory system morphology ( J:197147 )

• olfactory glomerular structures and axon bundles are somewhat altered

abnormal olfactory system physiology ( J:197147 )

abnormal olfactory sensory neuron physiology ( J:197147 )

• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT

• "electro-olfactogram" response to all odorants is significantly diminished

• TEA response becomes positive rather than the typical negative

impaired olfaction ( J:197147 )

• mice deprived of food for 1 day take 518 seconds to find a buried food pellet scented with peanut butter whereas controls take 26-27 seconds

• all mice find the pellet rapidly when placed on the surface of the bedding

nervous system

abnormal olfactory sensory neuron physiology ( J:197147 )

• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT

• "electro-olfactogram" response to all odorants is significantly diminished

• TEA response becomes positive rather than the typical negative

respiratory system

abnormal olfactory sensory neuron physiology ( J:197147 )

• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT

• "electro-olfactogram" response to all odorants is significantly diminished

• TEA response becomes positive rather than the typical negative

Genotype
MGI:5912380

cn7

• Allelic Composition: Cfap69^{tm1c(KOMP)Wtsi}/Cfap69^{tm1c(KOMP)Wtsi}; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
• Cell Lines: EPD0713_1_E05

taste/olfaction

taste/olfaction phenotype ( J:242686 )

N • mice exhibit normal structure of the olfactory epithelium

abnormal olfactory sensory neuron physiology ( J:242686 )

• faster response kinetics and stimuli integration using amyl acetate and heptaldehyde

• neurons fire action potentials more faithfully in response to repeated stimuli compared with wild-type mice

impaired olfaction ( J:242686 )

• mice take longer to find a buried food pellet when a background of the same odor is present compared with wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:242686 )

N • mice exhibit normal feeding and mating behaviors

nervous system

abnormal olfactory sensory neuron physiology ( J:242686 )

• faster response kinetics and stimuli integration using amyl acetate and heptaldehyde

• neurons fire action potentials more faithfully in response to repeated stimuli compared with wild-type mice

respiratory system

abnormal olfactory sensory neuron physiology ( J:242686 )

• faster response kinetics and stimuli integration using amyl acetate and heptaldehyde

• neurons fire action potentials more faithfully in response to repeated stimuli compared with wild-type mice

Genotype
MGI:7581989

cn8

• Allelic Composition: Ano9^em1Uoh/Ano9^em1Uoh; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

abnormal olfactory behavior ( J:344977 )

• fail to show a preference for peanut butter odor

• fail to show an aversive reaction to 2-methyl butyric acid

• following reward training, fail to show preference for the trained scent, carvone

Genotype
MGI:6119583

cn9

• Allelic Composition: Omp^tm4(cre)Mom/Omp⁺; Ric8b^{tm1c(EUCOMM)Hmgu}/Ric8b^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory epithelium physiology ( J:247954 )

• cell death is 5X higher in olfactory epithelium than in controls

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

impaired olfaction ( J:247954 )

• in the buried-food-seeking test, mice take longer to locate food than controls

• in the odorant preference test, mice exhibit a reduced preference to milk and peanut butter relative to water

• mice do not exhibit avoidance behavior in response to the odorant butyric acid

mortality/aging

decreased survivor rate ( J:247954 )

• overall, 11% of homozygous pups survive rather than the expected 25%

postnatal lethality, incomplete penetrance ( J:247954 )

• some pups die immediately after birth, especially pups from a litter size greater than 6

craniofacial

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

growth/size/body

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

cellular

increased neuron apoptosis ( J:247954 )

• olfactory sensory neurons exhibit a 5 fold increase in cell death

nervous system

increased neuron apoptosis ( J:247954 )

• olfactory sensory neurons exhibit a 5 fold increase in cell death

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory bulb glomerular layer morphology ( J:247954 )

• number of glomeruli is reduced and average size of glomeruli is smaller than control

small olfactory bulb ( J:247954 )

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

respiratory system

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory epithelium physiology ( J:247954 )

• cell death is 5X higher in olfactory epithelium than in controls

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

behavior/neurological

behavior/neurological phenotype ( J:247954 )

N • mice do not exhibit anxiety, depression or mobility deficits

Genotype
MGI:6725130

cn10

• Allelic Composition: Omp^tm4(cre)Mom/Omp⁺; Gucy1b2^tm3Mom Ift88^tm1Bky/Gucy1b2^tm3Mom Ift88^tm1Bky
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

behavior/neurological

abnormal response to novel odor ( J:307157 )

• with IFT88 absent from type B olfactory sensory neurons, homozygotes fail to respond to NaHS by the usual dose-dependent avoidance behavior or the increased stress-induced self-grooming that occurs that occurs in controls, but respond with normal avoidance and increased self-grooming to hypoxia

homeostasis/metabolism

abnormal homeostasis ( J:307157 )

• Type B olfactory sensory neurons of the main olfactory epithelium respond normally to hypoxia but fail to respond to NaHS

Genotype
MGI:6379998

cn11

• Allelic Composition: Gnao1^tm4Lbi/Gnao1^tm4Lbi; Omp^tm4(cre)Mom/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

behavior/neurological

abnormal behavior ( J:279957 )

• due to the lack of vomeronasal perception of f-MKKFRW, homozygotes fail to display the normal avoidance behaviour to this core peptide of an enteric bacterial virulence regulator due to the lack of vomeronasal perception of f-MKKFRW, homozygotes fail to display the normal avoidance behaviour to this core peptide of an enteric bacterial virulence regulator due to the lack of vomeronasal perception of f-MKKFRW, homozygotes fail to display the normal avoidance behaviour to this core peptide of an enteric bacterial virulence regulator ue to the lack of vomeronasal perception of f-MKKFRW, homozygotes fail to display the normal avoidance behaviour to this core peptide of an enteric bacterial virulence regulator

nervous system

abnormal vomeronasal sensory neuron physiology ( J:279957 )

• fail to respond to the f-MKKFRW peptide, which is the core peptide motif from the enteric bacterial master virulence regulator MgrB