All Phenotypes Or8a1<tm28(cre)Mom> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Or8a1^tm28(cre)Mom
targeted mutation 28, Peter Mombaerts
MGI:3692997

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gnas^tm5.1Lsw/Gnas^tm5.1Lsw Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe}/Gt(ROSA)26Sor⁺ Or8a1^tm28(cre)Mom/Or8a1^tm27Mom	involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:5788923
cn2	Nrp1^tm2Ddg/Nrp1^tm2Ddg Or8a1^tm28(cre)Mom/Or8a1^tm28(cre)Mom Tg(CAG-Bgeo/GFP)21Lbe/?	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6117236
cn3	Gt(ROSA)26Sor^tm5Mom/? Or8a1^tm28(cre)Mom/?	involves: 129P2/OlaHsd * C57BL/6	MGI:5788565

Allelic Composition	Gnas^tm5.1Lsw/Gnas^tm5.1Lsw Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe}/Gt(ROSA)26Sor⁺ Or8a1^tm28(cre)Mom/Or8a1^tm27Mom
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnas^tm5.1Lsw mutation (1 available); any Gnas mutation (54 available)
Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Or8a1^tm27Mom mutation (1 available); any Or8a1 mutation (69 available)
Or8a1^tm28(cre)Mom mutation (2 available); any Or8a1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

taste/olfaction

taste/olfaction phenotype ( J:233447 )

N	• axons of OLFR151 expressing olfactory sensory neurons appear to co-converge and coalesce in glomerular formation correctly despite G-protein disruption during development

Allelic Composition	Nrp1^tm2Ddg/Nrp1^tm2Ddg Or8a1^tm28(cre)Mom/Or8a1^tm28(cre)Mom Tg(CAG-Bgeo/GFP)21Lbe/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1^tm2Ddg mutation (1 available); any Nrp1 mutation (84 available)
Or8a1^tm28(cre)Mom mutation (2 available); any Or8a1 mutation (69 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb development ( J:255954 )

• olfactory sensory neurons expressing the null allele of Nrp1 have an altered and variable pattern of glomeruli formation in the olfactory bulb, including ectopic glomeruli, but the labeled glomeruli do not show an anterior shift relative to Nrp1 wild type controls

Allelic Composition	Gt(ROSA)26Sor^tm5Mom/? Or8a1^tm28(cre)Mom/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm5Mom mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Or8a1^tm28(cre)Mom mutation (2 available); any Or8a1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

taste/olfaction

taste/olfaction phenotype ( J:233447 )

N	• axons of OLFR151 expressing olfactory sensory neurons appear to co-converge and coalesce in glomerular formation correctly despite G-protein disruption

abnormal olfactory sensory neuron physiology ( J:233447 )

• the olfactory sensory neurons expressing the dominant negative GNAS exhibit reduced numbers of spontaneous spikes and a significantly higher instantaneous firing frequency in perforated patch-clamp recordings

nervous system

abnormal olfactory sensory neuron physiology ( J:233447 )

respiratory system

abnormal olfactory sensory neuron physiology ( J:233447 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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