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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flt1tm1Gne
targeted mutation 1, Genentech
MGI:3693075
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Flt1tm1Gne/Flt1tm1Gne Not Specified MGI:3693882


Genotype
MGI:3693882
hm1
Allelic
Composition		 Flt1tm1Gne/Flt1tm1Gne
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm1Gne mutation (0 available); any Flt1 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cornea vascularization ( J:114973 )
• corneal inection of plasmids encoding cre recombinase to delete Flt1 in the cornea induces corneal vascularization, but has no effect in wild-type mice; topical application of cell-permeable cre to the cornea to avoid trauma also induces vascularization in mutants but not wild-type

cardiovascular system
cornea vascularization ( J:114973 )
• corneal inection of plasmids encoding cre recombinase to delete Flt1 in the cornea induces corneal vascularization, but has no effect in wild-type mice; topical application of cell-permeable cre to the cornea to avoid trauma also induces vascularization in mutants but not wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory