Phenotypes associated with this allele

• Allele Symbol: Jag1^tm2.1Grid
• Allele Name: targeted mutation 2.1, Tom Gridley
• Allele ID: MGI:3693129
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jag1^tm2.1Grid/Jag1^tm2.1Grid	involves: 129S1/Sv * C57BL/6	MGI:3693199

Genotype
MGI:3693199

hm1

• Allelic Composition: Jag1^tm2.1Grid/Jag1^tm2.1Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:115783 )

• all homozygous embryos are necrotic by E11.5

embryo

abnormal vitelline vascular remodeling ( J:115783 )

• homozygotes exhibit yolk sac vascular remodeling defects; most show vascular defects by E10.5

cardiovascular system

distended pericardium ( J:115783 )

• an enlarged pericardial sac is often seen in homozygotes

intracranial hemorrhage ( J:115783 )

nervous system

intracranial hemorrhage ( J:115783 )