Analysis Tools
cardiovascular system
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• adult hearts show myocyte disarray and degeneration, mild inflammatory cell infiltration, occasional hypertrophied cells, and minimal fibrosis
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• isolated myofilament lysis and discontinuity in adult ventricular myocytes
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• decrease in myocyte size that results in a decrease in ventricular mass
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• adult hearts show myocyte degeneration
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small heart
(
J:104369
)
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• hearts are smaller
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• heart weigh/body weight ratio is smaller
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• ventricular mass is decreased by 14% in 6 month old mice
• 6 month old mice exhibit mild degrees of myofibrillar lysis and prominent atrial natriuretic factor granules in left ventricular tissue
• however, no sarcomere loss or destruction, mitochondrial abnormalities, or apoptotic nuclei are seen in left ventricular tissue
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• hearts exhibit impaired systolic performance at baseline and with inotropic challenge
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• diastolic function, as indicated by increases in end-diastolic pressure and decreases in the rate of relaxation, is impaired, with hearts unable to increase their rate of relaxation in response to increased perfusate of calcium
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• hearts are less able to increase developed pressure upon inotropic challenge
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• left ventricular systolic pressure and the rate of pressure development (+dP/dt) are lower in response to increasing calcium concentrations
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• hearts exhibit a more severe cardiomyopathy than Tg(Myh6-Tnnt2*R92L)1Jcf /0 mice
• maker analysis shows early activation of the fetal gene or hypertrophic gene program indicating early disease onset, however, overt ventricular hypertrophy is not seen
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muscle
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• isolated myofilament lysis and discontinuity in adult ventricular myocytes
|
|
• decrease in myocyte size that results in a decrease in ventricular mass
|
|
• adult hearts show myocyte degeneration
|
|
• hearts exhibit impaired systolic performance at baseline and with inotropic challenge
|
|
• diastolic function, as indicated by increases in end-diastolic pressure and decreases in the rate of relaxation, is impaired, with hearts unable to increase their rate of relaxation in response to increased perfusate of calcium
|
|
• hearts exhibit a more severe cardiomyopathy than Tg(Myh6-Tnnt2*R92L)1Jcf /0 mice
• maker analysis shows early activation of the fetal gene or hypertrophic gene program indicating early disease onset, however, overt ventricular hypertrophy is not seen
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• adult ventricular myocytes exhibit dilated sarcomeric reticulum
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypertrophic cardiomyopathy 2 | DOID:0110308 |
OMIM:115195 |
J:104369 | |
