Phenotypes associated with this allele

• Allele Symbol: Kmt2c^tm1.1Jwle
• Allele Name: targeted mutation 1.1, Jae Lee
• Allele ID: MGI:3693319
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2c^tm1.1Jwle/Kmt2c^tm1.1Jwle	involves: 129S4/SvJae * 129X1/SvJ	MGI:3693878
cx2	Kmt2c^tm1.1Jwle/Kmt2c^+ Kmt2d^Gt(RRT024)Byg/Kmt2d^+	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:6515624

Genotype
MGI:3693878

hm1

• Allelic Composition: Kmt2c^tm1.1Jwle/Kmt2c^tm1.1Jwle
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Phenotypes of the Kmt2c^tm1.1Jwle/Kmt2c^tm1.1Jwle mouse

mortality/aging

embryonic lethality, incomplete penetrance ( J:116064 )

• occasional embryos undergoing necrosis are observed

growth/size/body

postnatal growth retardation ( J:116064 )

• overall growth retardation is observed

• mutants weigh ~30-40% less than wild-type at birth, and remain ~20% smaller through adulthood

reproductive system

female infertility ( J:116064 )

♀ • female mutants are infertile to hypofertile

reduced female fertility ( J:116064 )

♀ • female mutants are infertile to hypofertile

reduced male fertility ( J:116064 )

♂ • male mutants are hypofertile

vision/eye

delayed eyelid opening ( J:116064 )

• homozygotes display delayed eyelid opening

cellular

decreased cell proliferation ( J:116064 )

• mouse embryonic fibroblasts (MEFs) isolated from mutants double at ~half the rate of wild-type cells in culture

Genotype
MGI:6515624

cx2

• Allelic Composition: Kmt2c^tm1.1Jwle/Kmt2c⁺; Kmt2d^{Gt(RRT024)Byg}/Kmt2d⁺
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

growth/size/body

decreased body fat mass ( J:301497 )

• mice exhibit decreased body fat mass percentage at 15 weeks of age

decreased body weight ( J:301497 )

• mice exhibit decreased body weight at 7 weeks of age

adipose tissue

decreased body fat mass ( J:301497 )

• mice exhibit decreased body fat mass percentage at 15 weeks of age

homeostasis/metabolism

improved glucose tolerance ( J:301497 )

increased insulin sensitivity ( J:301497 )

increased bile salt level ( J:301497 )

• mice exhibit increased serum bile acid levels