Phenotypes associated with this allele

• Allele Symbol: Cdc42^tm1Yizh
• Allele Name: targeted mutation 1, Yi Zheng
• Allele ID: MGI:3693320
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdc42^tm1Yizh/Cdc42^tm1Yizh Foxg1^tm1(cre)Skm/Foxg1^+	involves: 129P2/OlaHsd	MGI:3693870

Genotype
MGI:3693870

cn1

• Allelic Composition: Cdc42^tm1Yizh/Cdc42^tm1Yizh; Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:116100 )

• numbers of homozygotes starts to decline after E13.5

nervous system

abnormal embryonic neuroepithelium morphology ( J:116100 )

• mutant embryos display a much thicker neuroepithelium (NE) wall, and a lack of telencephalic vesicle enlargement in the developing forebrain at E10.5

• roof plate has thinner NE wall and lacked invagination of dorsal telencephalon

• apical-basal polarity of NE of developing forebrain is disrupted

abnormal telencephalon development ( J:116100 )

• at E12.5, telencephalon remains single chambered and clear distinction between cortical plate and ganglionic eminences is absent

• in E11.5 mutants, neural progenitors and postmitotic neurons are intermingled throughout NE but in wild-type brain, progenitors are mainly confined to ventricular surface of forebrain and postmitotic neurons are found along apical-basal NE axis

abnormal folding of telencephalic vesicles ( J:116100 )

• roof plate lacks invagination of dorsal telencephalon at E12.5

small embryonic telencephalon ( J:116100 )

• between E9.5-12.5, mutants do not exhibit enlargement of telencephalic vesicles in contrast to wild-type embryos

holoprosencephaly ( J:116100 )

vision/eye

abnormal eye development ( J:116100 )

• in E9.5-12.5 mutants, eye development is delayed compared to wild-type

embryo

abnormal embryonic neuroepithelium morphology ( J:116100 )

• mutant embryos display a much thicker neuroepithelium (NE) wall, and a lack of telencephalic vesicle enlargement in the developing forebrain at E10.5

• roof plate has thinner NE wall and lacked invagination of dorsal telencephalon

• apical-basal polarity of NE of developing forebrain is disrupted