Analysis Tools
vision/eye
|
• defects are observed starting at E10.5
• reduction in size of invaginating lens pit is observed in mildly and moderately affected embryos
• at E14.5, some embryos have an abnormally persistent lens stalk
• differentiation of lens is not affected in mildly or moderately affected mutant lenses
|
|
• in severely affected lenses at E10.5, no lens-like structures are present
|
|
• at E12.5, in mild cases, lens vesicle is small but relatively normal, small and abnormal in moderated cases and completely absent in severely affected embryos and neuroretinal is malformed also
|
|
• at E14.5 some embryos show disorganized lens fibers
|
small lens
(
J:116102
)
|
• some mice show drastically reduced lens size
|
|
• shape of vesicle is defective
|
