Phenotypes associated with this allele

• Allele Symbol: Ret^tm3Cos
• Allele Name: targeted mutation 3, Frank Costantini
• Allele ID: MGI:3693325
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm3Cos/Ret^tm3Cos	involves: 129S1/Sv * FVB/N	MGI:3693829

Genotype
MGI:3693829

hm1

• Allelic Composition: Ret^tm3Cos/Ret^tm3Cos
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal enteric neural crest cell morphology ( J:116089 )

• number of lamellipodia is not significantly different on proximal and distal sides of ENCCs, indicating a decrease; in wild-type ENCCs, lamellipodia number is significantly greater in proximal side vs distal side

abnormal enteric ganglia morphology ( J:116089 )

• homozygotes display severe reduction of myenteric plexus in distal colon; enteric ganglia are absent in terminal one-third and reduced in number in middle one-third of colon

abnormal enteric neuron morphology ( J:116089 )

• homozygotes display severe reduction of myenteric plexus in distal colon; neuron number is markedly reduced in middle portion of colon and dramatically reduced in terminal portion

absent enteric neurons ( J:116089 )

• enteric ganglia (neurons) are absent in terminal portion of colon

digestive/alimentary system

abnormal colon morphology ( J:116089 )

• enteric ganglia are absent in terminal one-third of colon

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:116089 )

• c-Jun N-terminal kinase (JNK) activity is impaired in mutants, resulting in impaired ENCC migration

embryo

abnormal enteric neural crest cell migration ( J:116089 )

• enteric neural crest cell (ENCC) migration is impaired in the developing gut

abnormal enteric neural crest cell morphology ( J:116089 )

• number of lamellipodia is not significantly different on proximal and distal sides of ENCCs, indicating a decrease; in wild-type ENCCs, lamellipodia number is significantly greater in proximal side vs distal side

cellular

abnormal enteric neural crest cell migration ( J:116089 )

• enteric neural crest cell (ENCC) migration is impaired in the developing gut