Phenotypes associated with this allele

• Allele Symbol: Tg(APPSwLon)96Btla
• Allele Name: transgene insertion 96, Bruce Lamb
• Allele ID: MGI:3693359
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(APPSwLon)96Btla/0 Tg(PSEN1H163R)G9Btla/0	involves: 129S4/SvJae	MGI:3693492
tg2	Tg(APPSwLon)96Btla/Tg(APPSwLon)96Btla	involves: 129S4/SvJae	MGI:3693506
tg3	Tg(APPSwLon)96Btla/0	involves: 129S4/SvJae	MGI:3693440

Genotype
MGI:3693492

cx1

• Allelic Composition: Tg(APPSwLon)96Btla/0; Tg(PSEN1H163R)G9Btla/0
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:58050 )

• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

homeostasis/metabolism

amyloid beta deposits ( J:58050 )

• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

Genotype
MGI:3693506

tg2

• Allelic Composition: Tg(APPSwLon)96Btla/Tg(APPSwLon)96Btla
• Genetic Background: involves: 129S4/SvJae

nervous system

nervous system phenotype ( J:58050 )

N • no Alzheimer's disease pathology is observed at 2 years of age in homozygotes

amyloid beta deposits ( J:58050 )

• homzygous mice have 4- to 6-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes

homeostasis/metabolism

amyloid beta deposits ( J:58050 )

• homzygous mice have 4- to 6-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes

Genotype
MGI:3693440

tg3

• Allelic Composition: Tg(APPSwLon)96Btla/0
• Genetic Background: involves: 129S4/SvJae

nervous system

nervous system phenotype ( J:58050 )

N • no Alzheimer's disease pathology is observed at 2 years of age in homozygotes

amyloid beta deposits ( J:42613 , J:58050 )

• mice have much higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APPSw)40Btla mutant mice or Tg(APP)8.9Btla mice (J:42613)

• hemizygous mice have 2- to 3-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

homeostasis/metabolism

amyloid beta deposits ( J:42613 , J:58050 )

• mice have much higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APPSw)40Btla mutant mice or Tg(APP)8.9Btla mice (J:42613)

• hemizygous mice have 2- to 3-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:42613