Phenotypes associated with this allele

• Allele Symbol: Ccni^tm1Jro
• Allele Name: targeted mutation 1, James M Roberts
• Allele ID: MGI:3693371
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccni^tm1Jro/Ccni^tm1Jro	involves: 129S4/SvJaeSor	MGI:3693619

Genotype
MGI:3693619

hm1

• Allelic Composition: Ccni^tm1Jro/Ccni^tm1Jro
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating creatinine level ( J:115356 )

• at day 14 of induced disease, creatinine levels continue to rise markedly in mutants (2.3 mg/dl) vs 0.86 mg/dl in wild-type

increased urine protein level ( J:115356 )

• nephritic mutants develop proteinuria faster than nephritic wild-type mice; increased proteinuria persists at day 14 of disease

renal/urinary system

increased podocyte apoptosis ( J:115356 )

• cultured mutant podocytes display earlier and greater levels of apoptosis induced by irradiation with uv-C, puromycin aminonucleoside treatment or anti-podocyte antibody, than wild-type cells

increased renal glomerulus apoptosis ( J:115356 )

• a 4-fold increase in glomerular cell apoptosis is observed in mutant mice at day 7 after induction of nephritis

increased urine protein level ( J:115356 )

• nephritic mutants develop proteinuria faster than nephritic wild-type mice; increased proteinuria persists at day 14 of disease

decreased podocyte number ( J:115356 )

• decreased podocyte numbers are observed in mutants at 14 days after induction of nephritis relative to wild-type controls

glomerulosclerosis ( J:115356 )

• extensive involvement of glomerulosclerosis (indicated by fibronectin accumulation) in mutant mice has occurred by day 14 of glomerulonephritis in mutants compared to wild-type

kidney failure ( J:115356 )

• upon induction of glomerular nephritis, mutants develop renal failure by day 7, similar to wild-type mice with induced disease

cellular

increased podocyte apoptosis ( J:115356 )

• cultured mutant podocytes display earlier and greater levels of apoptosis induced by irradiation with uv-C, puromycin aminonucleoside treatment or anti-podocyte antibody, than wild-type cells

increased renal glomerulus apoptosis ( J:115356 )

• a 4-fold increase in glomerular cell apoptosis is observed in mutant mice at day 7 after induction of nephritis