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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Or8a1tm29Mom
targeted mutation 29, Peter Mombaerts
MGI:3693508
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Or8a1tm29Mom/Or8a1tm29Mom involves: 129P2/OlaHsd * C57BL/6J MGI:3696088
ht2
 		Or8a1tm26Mom/Or8a1tm29Mom involves: 129P2/OlaHsd * C57BL/6J MGI:3696090


Genotype
MGI:3696088
hm1
Allelic
Composition		 Or8a1tm29Mom/Or8a1tm29Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm29Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:115911 )
• fewer cells expressing the mutant allele are present compared to control mice expressing Olfr151 promotor driven LacZ transgene
abnormal olfactory bulb morphology ( J:115911 )
• olfactory sensory neuron axons form ectopic, ventral glomeruli in the olfactory bulb in addition to glomeruli in the expected position
• two pairs of glomeruli are present in 44% of bulbs
• presence of extra glomeruli correlates to presence of 12-fold fewer cells in dorsal regions and 4- to 10-fold more cells in theventral region of the epithelium of endoturbinates II and III

craniofacial
abnormal olfactory sensory neuron morphology ( J:115911 )
• fewer cells expressing the mutant allele are present compared to control mice expressing Olfr151 promotor driven LacZ transgene

respiratory system
abnormal olfactory sensory neuron morphology ( J:115911 )
• fewer cells expressing the mutant allele are present compared to control mice expressing Olfr151 promotor driven LacZ transgene

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:115911 )
• fewer cells expressing the mutant allele are present compared to control mice expressing Olfr151 promotor driven LacZ transgene

growth/size/body
abnormal olfactory sensory neuron morphology ( J:115911 )
• fewer cells expressing the mutant allele are present compared to control mice expressing Olfr151 promotor driven LacZ transgene




Genotype
MGI:3696090
ht2
Allelic
Composition		 Or8a1tm26Mom/Or8a1tm29Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm26Mom mutation (3 available); any Or8a1 mutation (69 available)
Or8a1tm29Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:115911 )
• olfactory sensory neuron axons form ectopic, ventral glomeruli in the olfactory bulb either with or without the presence of glomeruli in the expected position
• when only ectopic glomeruli are present both red and green axons are present; however when two pairs of glomeruli are present the ectopic glomeruli contain primarily red axons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory