All Phenotypes Hnrnpd<tm1Rjsc> MGI Mouse

abnormal macrophage physiology ( J:116112 )

• in primary macrophages stimulated with LPS production of TNFA and IL-1B are increased by 40% and 70% respectively

• increased expression of TNFA and IL-1B is maintained for a longer period than in wild-type cells

increased circulating tumor necrosis factor level ( J:116112 )

• after LPS challenge, peripheral blood TNFA levels are increased by 30% compared to wild-type mice

increased susceptibility to endotoxin shock ( J:116112 )

• when given 20 mg/kg of LPS mice display an almost 5-fold increase in mortality (47.4% compared to 10% in wild-type mice)

increased susceptibility to bacterial infection ( J:116112 )

• when given 20 mg/kg of LPS mice display an almost 5-fold increase in mortality (47.4% compared to 10% in wild-type mice)

• surviving mice take about twice as long to recover after exposure to 20 mg/kg LPS

• following LPS challenge kidney hemorrhagic lesions are increased in number and size, blood urea nitrogen and serum aspartate aminotransferase levels are increased, intravascular coagulation is common in the kidneys, liver, and lung, and TNFA levels are higher

• injection of antibodies to neutralize TNFA and IL-1B reduces the response to LPS and protects against lethality

decreased birth body size ( J:116112 )

• newborns are smaller than normal

decreased birth weight ( J:116112 )

• newborns display reduced body weight

decreased body size ( J:116112 )

• in young adults

decreased body weight ( J:116112 )

• in young adults

fetal growth retardation ( J:116112 )

• seen equally in both sexes at birth

kidney hemorrhage ( J:116112 )

• following LPS challenge kidney hemorrhagic lesions are increased in number and size relative to LPS-challenged wild-type mice

increased blood urea nitrogen level ( J:116112 )

• following LPS challenge, relative to LPS-challenged wild-type mice