All Phenotypes Smad4<tm1Rdp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smad4^tm1Rdp
targeted mutation 1, Ronald DePinho
MGI:3693621

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm1Rdp/Pten^tm1Rdp Smad4^tm1Rdp/Smad4^tm1Rdp Trp53^tm1Brn/Trp53^tm1Brn Tg(Pbsn-cre)4Prb/0	involves: 129 * C57BL/6 * DBA/2	MGI:5431947
cn2	Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Smad4^tm1Rdp/Smad4^tm1Rdp	involves: 129 * FVB/N	MGI:3695420
cn3	Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	involves: 129 * FVB/N	MGI:3695421
cn4	Cdkn2a^tm4Rdp/Cdkn2a⁺ Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	involves: 129 * FVB/N	MGI:3695424
cn5	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	involves: 129 * FVB/N	MGI:3695428
cn6	Smad4^tm1Rdp/Smad4^tm1.1Rdp Trim33^tm1.1Los/Trim33^tm1.2Los Tg(CAG-cre)13Miya/0	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL	MGI:4830328
cn7	Smad4^tm1Rdp/Smad4^tm1.1Rdp Tg(CAG-cre)13Miya/0	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL	MGI:4830329
cn8	Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N	MGI:3695422
cn9	Cdkn2a^tm4Rdp/Cdkn2a⁺ Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N	MGI:3695426
cn10	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N	MGI:3695429
cn11	Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0	involves: 129S/SvEv * C57BL/6 * CBA * FVB/N	MGI:3695419
cn12	Cdkn2a^tm4Rdp/Cdkn2a⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0	involves: 129S/SvEv * C57BL/6 * CBA * FVB/N	MGI:3695427

Allelic Composition	Pten^tm1Rdp/Pten^tm1Rdp Smad4^tm1Rdp/Smad4^tm1Rdp Trp53^tm1Brn/Trp53^tm1Brn Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Rdp mutation (0 available); any Pten mutation (88 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:186105 )

• survival time is shorter than in mutant mice wild-type for Smad4

• median survival time of 17.05 weeks

neoplasm

increased prostate gland adenocarcinoma incidence ( J:186105 )

• all develop rapidly progressive, locally invasive prostate adenocarcinomas

• tumors are more aggressive than in mutant mice wild-type for Smad4

increased metastatic potential ( J:186105 )

• bone metastases are seen in some (3 of 24) mice unlike in mutant mice wild-type for Smad4

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:186105 )

• all develop rapidly progressive, locally invasive prostate adenocarcinomas

• tumors are more aggressive than in mutant mice wild-type for Smad4

reproductive system

increased prostate gland adenocarcinoma incidence ( J:186105 )

• all develop rapidly progressive, locally invasive prostate adenocarcinomas

• tumors are more aggressive than in mutant mice wild-type for Smad4

Allelic Composition	Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Smad4^tm1Rdp/Smad4^tm1Rdp
Genetic Background	involves: 129 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (31 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:116130 )

N	• pancreatic development, morphology, and function are all similar to wild-type and no pancreatic neoplasms develop

Allelic Composition	Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	involves: 129 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (31 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

pancreas cyst ( J:116130 )

• seen in all mice

mortality/aging

decreased tumor-free survival time ( J:116130 )

• mice die between 8 and 24 weeks of age

• average tumor-free survival is 15.7 weeks

neoplasm

increased tumor incidence ( J:116130 )

• 12 of 12 mice develop intraductal papillary mucinous neoplasms

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 2 of 12 mice develop pancreatic ductal adenocarcinoma

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 2 of 12 mice develop pancreatic ductal adenocarcinoma

pancreas cyst ( J:116130 )

• seen in all mice

Allelic Composition	Cdkn2a^tm4Rdp/Cdkn2a⁺ Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	involves: 129 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm4Rdp mutation (0 available); any Cdkn2a mutation (67 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (31 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 12 of 13 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

mortality/aging

decreased tumor-free survival time ( J:116130 )

• average tumor-free survival is 14 weeks

neoplasm

increased tumor incidence ( J:116130 )

• 5 of 13 mice develop intraductal papillary mucinous neoplasms

• tumor fibrosis is increased compared to mice wild-type for Smad4

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 12 of 13 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

Allelic Composition	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	involves: 129 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 4 of 4 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

• tumor fibrosis is increased compared to mice wild-type for Smad4

mortality/aging

decreased tumor-free survival time ( J:116130 )

• average tumor-free survival is 8.8 weeks

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 4 of 4 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

• tumor fibrosis is increased compared to mice wild-type for Smad4

Allelic Composition	Smad4^tm1Rdp/Smad4^tm1.1Rdp Trim33^tm1.1Los/Trim33^tm1.2Los Tg(CAG-cre)13Miya/0
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4^tm1.1Rdp mutation (0 available); any Smad4 mutation (48 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(CAG-cre)13Miya mutation (1 available)
Trim33^tm1.1Los mutation (0 available); any Trim33 mutation (71 available)
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:163858 )

• identical to mice null for Smad4 alone

absent anterior visceral endoderm ( J:163858 )

• not induced at E5.5

Allelic Composition	Smad4^tm1Rdp/Smad4^tm1.1Rdp Tg(CAG-cre)13Miya/0
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:163858 )

• stated to phenocopy mice homozygous for Smad4^tm1Cxd

absent anterior visceral endoderm ( J:163858 )

• not induced at E5.5

Allelic Composition	Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

increased stomach tumor incidence ( J:116130 )

• 5 of 8 mice develop gastric cancer with squamous or adenosquamous histology

mortality/aging

decreased tumor-free survival time ( J:116130 )

• mice die between 8 and 24 weeks of age

• average tumor-free survival is 13.1 weeks

endocrine/exocrine glands

pancreas cyst ( J:116130 )

• seen in all mice

growth/size/body

pancreas cyst ( J:116130 )

• seen in all mice

neoplasm

increased tumor incidence ( J:116130 )

• 5 of 8 mice develop intraductal papillary mucinous neoplasms

increased stomach tumor incidence ( J:116130 )

• 5 of 8 mice develop gastric cancer with squamous or adenosquamous histology

Allelic Composition	Cdkn2a^tm4Rdp/Cdkn2a⁺ Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm4Rdp mutation (0 available); any Cdkn2a mutation (67 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:116130 )

• average tumor-free survival is 12.6 weeks

neoplasm

increased tumor incidence ( J:116130 )

• 4 of 12 mice develop intraductal papillary mucinous neoplasms

• tumor fibrosis is increased compared to mice wild-type for Smad4

increased stomach tumor incidence ( J:116130 )

• 8 of 12 mice develop gastric cancer

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 4 of 12 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

digestive/alimentary system

increased stomach tumor incidence ( J:116130 )

• 8 of 12 mice develop gastric cancer

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 4 of 12 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

Allelic Composition	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Kras^tm4Tyj/Kras⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm4Rdp mutation (0 available); any Cdkn2a mutation (67 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:116130 )

• average tumor-free survival is 7.4 weeks

neoplasm

increased tumor incidence ( J:116130 )

• 3 of 10 mice develop intraductal papillary mucinous neoplasms

• tumor fibrosis is increased compared to mice wild-type for Smad4

increased stomach tumor incidence ( J:116130 )

• 5 of 10 mice develop gastric cancer

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 9 of 10 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

digestive/alimentary system

increased stomach tumor incidence ( J:116130 )

• 5 of 10 mice develop gastric cancer

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:116130 )

• 9 of 10 mice develop pancreatic ductal adenocarcinoma

• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

Allelic Composition	Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

duodenum polyps ( J:116130 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:116130 )

N	• pancreatic development, morphology, and function are all similar to wild-type and no pancreatic neoplasms develop

Allelic Composition	Cdkn2a^tm4Rdp/Cdkn2a⁺ Smad4^tm1Rdp/Smad4^tm1Rdp Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm4Rdp mutation (0 available); any Cdkn2a mutation (67 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:116130 )

N	• tumor-free survival is greater than 52 weeks and only 1 of 10 mice developed an intraductal papillary mucinous neoplasm

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