All Phenotypes Eps8<tm1Ppdf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eps8^tm1Ppdf
targeted mutation 1, Pier Paolo Di Fiore
MGI:3693626

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eps8^tm1Ppdf/Eps8^tm1Ppdf	B6.129P2-Eps8^tm1Ppdf	MGI:3695435
hm2	Eps8^tm1Ppdf/Eps8^tm1Ppdf	involves: 129P2/OlaHsd	MGI:3695434
hm3	Eps8^tm1Ppdf/Eps8^tm1Ppdf	involves: 129P2/OlaHsd * C57BL/6J	MGI:5544330
cx4	Eps8^tm1Ppdf/Eps8^tm1Ppdf Eps8l2^tm1Wma/Eps8l2^tm1Wma	involves: 129P2/OlaHsd * C57BL/6J	MGI:5544329

Allelic Composition	Eps8^tm1Ppdf/Eps8^tm1Ppdf
Genetic Background	B6.129P2-Eps8^tm1Ppdf

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eps8^tm1Ppdf mutation (0 available); any Eps8 mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

alcohol preference ( J:116055 )

• mice show a preference for ethanol over water

increased alcohol consumption ( J:116055 )

• mutants show increased ethanol consumption compared to wild-type

abnormal motor capabilities/coordination/movement ( J:116055 )

• mice exposed to increasing ethanol concentrations remain on rotating rod significantly longer than controls

improved righting response ( J:116055 )

• after ethanol administration, righting reflex recovers significantly faster than in wild-type

nervous system

abnormal excitatory postsynaptic currents ( J:116055 )

• NMDA component of excitatory post synaptic currents is 2-fold higher compared to controls

• 400 mM ethanol reduces NMDA current in wild-type neurons (from 41% to 92% in presence of 100mM and 400 mM ethanol, respectively), but in mutants reduction remains ~40% at both concentrations

enhanced NMDA-mediated synaptic currents ( J:116055 )

• NMDA component of excitatory post synaptic currents is 2-fold higher compared to controls

cellular

abnormal cell physiology ( J:116055 )

• ethanol does not induce actin remodeling in mutants as it does in controls

Allelic Composition	Eps8^tm1Ppdf/Eps8^tm1Ppdf
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eps8^tm1Ppdf mutation (0 available); any Eps8 mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:116237 )

• mice display no obvious abnormal phenotype

Allelic Composition	Eps8^tm1Ppdf/Eps8^tm1Ppdf
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eps8^tm1Ppdf mutation (0 available); any Eps8 mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

short cochlear hair cell stereocilia ( J:200669 )

nervous system

short cochlear hair cell stereocilia ( J:200669 )

Allelic Composition	Eps8^tm1Ppdf/Eps8^tm1Ppdf Eps8l2^tm1Wma/Eps8l2^tm1Wma
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eps8l2^tm1Wma mutation (0 available); any Eps8l2 mutation (38 available)
Eps8^tm1Ppdf mutation (0 available); any Eps8 mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Disorganized stereocilia in Eps8l2^tm1Wma/Eps8l2^tm1Wma Eps8^tm1Ppdf/Eps8^tm1Ppdf mice

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:200669 )

• hair bundle abnormalities are strongly enhanced compared to single mutants

• profoundly disorganized

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:200669 )

• hair bundle abnormalities are strongly enhanced compared to single mutants

• profoundly disorganized

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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