Phenotypes associated with this allele

• Allele Symbol: Hdac7^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:3693627
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdac7^tm1Eno/Hdac7^tm1Eno	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)	MGI:3695493
cn2	Hdac7^tm1Eno/Hdac7^tm2Eno Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3695494

Genotype
MGI:3695493

hm1

• Allelic Composition: Hdac7^tm1Eno/Hdac7^tm1Eno
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:116008 )

• homozygous embryos are detected in normal numbers to E11 but no viable embryos are found after that

embryo

abnormal pharyngeal arch artery morphology ( J:116008 )

• arteries are grossly enlarged at E11

cardiovascular system

abnormal dorsal aorta morphology ( J:116008 )

• at E11, embryos have enlarged dorsal aortae; frequently the dorsal aorta is ruptured; fewer smooth muscle cells than normal surround the dorsal aorta

abnormal pharyngeal arch artery morphology ( J:116008 )

• arteries are grossly enlarged at E11

abnormal vascular endothelial cell morphology ( J:116008 )

• epithelial cells extend processes that fail to establish tight cell-dell interactions

abnormal cardinal vein morphology ( J:116008 )

• at E11, cardinal veins are severely enlarged and frequently ruptured

abnormal vasculogenesis ( J:116008 )

• tight junctions between endothelial cells are often missing in embryos prior to death

• there are large intracellular spaces between endothelial cells and surrounding smooth muscle cells

dilated heart atrium ( J:116008 )

• atria in embryos are dilated at E11

thin ventricular wall ( J:116008 )

• myocardial walls are abnormally thin

pericardial effusion ( J:116008 )

• at E11, embryos display pericardial effusion

internal hemorrhage ( J:116008 )

• at E11, embryos show widespread vascular hemorrhage

craniofacial

abnormal pharyngeal arch artery morphology ( J:116008 )

• arteries are grossly enlarged at E11

homeostasis/metabolism

pericardial effusion ( J:116008 )

• at E11, embryos display pericardial effusion

Genotype
MGI:3695494

cn2

• Allelic Composition: Hdac7^tm1Eno/Hdac7^tm2Eno; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

mortality/aging

embryonic lethality, complete penetrance ( J:116008 )

• embryos die by E11.5

homeostasis/metabolism

edema ( J:116008 )

cardiovascular system

abnormal cardiovascular system morphology ( J:116008 )

• embryos show all cardiovascular features of the Hdac7a^tm1Eno

dilated dorsal aorta ( J:116008 )

• enlargement of aorta is less severe than in Hdac7a^tm1Eno mutants

abnormal vascular endothelial cell morphology ( J:116008 )

• endothelial elongation is observed

abnormal vascular smooth muscle morphology ( J:116008 )

• embryos show a reduction in number of arterial smooth muscle cells

internal hemorrhage ( J:116008 )

• embryos show multifocal hemorrhages

muscle

abnormal vascular smooth muscle morphology ( J:116008 )

• embryos show a reduction in number of arterial smooth muscle cells