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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac7tm2Eno
targeted mutation 2, Eric N Olson
MGI:3693628
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hdac7tm1Eno/Hdac7tm2Eno
Tg(Tek-cre)1Ywa/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3695494


Genotype
MGI:3695494
cn1
Allelic
Composition		 Hdac7tm1Eno/Hdac7tm2Eno
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac7tm1Eno mutation (0 available); any Hdac7 mutation (49 available)
Hdac7tm2Eno mutation (0 available); any Hdac7 mutation (49 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

homeostasis/metabolism

cardiovascular system
abnormal cardiovascular system morphology ( J:116008 )
• embryos show all cardiovascular features of the Hdac7atm1Eno
dilated dorsal aorta ( J:116008 )
• enlargement of aorta is less severe than in Hdac7atm1Eno mutants
abnormal vascular endothelial cell morphology ( J:116008 )
• endothelial elongation is observed
abnormal vascular smooth muscle morphology ( J:116008 )
• embryos show a reduction in number of arterial smooth muscle cells
internal hemorrhage ( J:116008 )
• embryos show multifocal hemorrhages

muscle
abnormal vascular smooth muscle morphology ( J:116008 )
• embryos show a reduction in number of arterial smooth muscle cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory