Phenotypes associated with this allele

• Allele Symbol: Fn3k^tm1Mvdc
• Allele Name: targeted mutation 1, Maria Veiga-Da-Cunha
• Allele ID: MGI:3693634
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fn3k^tm1Mvdc/Fn3k^tm1Mvdc	involves: 129S1/Sv * 129X1/SvJ	MGI:3695315

Genotype
MGI:3695315

hm1

• Allelic Composition: Fn3k^tm1Mvdc/Fn3k^tm1Mvdc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:116037 )

• mutants show 5-13-fold higher tissue and cell content of fructoselysine, except in kidney, compared to controls

• mutants have ~2.5-fold higher concentration of glycated proteins compared to controls

homeostasis/metabolism

abnormal urine homeostasis ( J:116037 )

• urinary excretion of fructoselysine is 10-20-fold lower in fasted mice than fed mice

• excretion is 2.5-fold greater in fasted mutants than fasted wild-type

renal/urinary system

abnormal urine homeostasis ( J:116037 )

• urinary excretion of fructoselysine is 10-20-fold lower in fasted mice than fed mice

• excretion is 2.5-fold greater in fasted mutants than fasted wild-type