Phenotypes associated with this allele

• Allele Symbol: Polq^tm2Jow
• Allele Name: targeted mutation 2, Jiyang O-Wang
• Allele ID: MGI:3693648
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polq^tm2Jow/Polq^tm2Jow	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3695306

Genotype
MGI:3695306

hm1

• Allelic Composition: Polq^tm2Jow/Polq^tm2Jow
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal somatic hypermutation frequency ( J:115989 )

• total somatic hypermutation in the JH4 intronic region in germinal center B cells is mildly, but significantly, reduced with similar effects on mutations at C/G and A/T and an increase in G to C transversions

• however, B cell differentiation and maturation, T-dependent immune responses, and serum Ig levels are all similar to wild-type

hematopoietic system

abnormal somatic hypermutation frequency ( J:115989 )

• total somatic hypermutation in the JH4 intronic region in germinal center B cells is mildly, but significantly, reduced with similar effects on mutations at C/G and A/T and an increase in G to C transversions

• however, B cell differentiation and maturation, T-dependent immune responses, and serum Ig levels are all similar to wild-type