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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lat2tm2Wz
targeted mutation 2, Weiguo Zhang
MGI:3693652
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lat2tm2Wz/Lat2tm2Wz
Tg(Lck-cre)548Jxm/0 		involves: C57BL/6 MGI:3695390


Genotype
MGI:3695390
cn1
Allelic
Composition		 Lat2tm2Wz/Lat2tm2Wz
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm2Wz mutation (0 available); any Lat2 mutation (19 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:116157 )
• at 6 months of age
increased activated T cell number ( J:116157 )
• increased number of activated CD4 cells at 6 months of age
abnormal CD4-positive, alpha-beta T cell physiology ( J:116157 )
• increased production of IL-2, IL-10, and IFNG
increased anti-double stranded DNA antibody level ( J:116157 )
• high titers of dsDNA antibodies are present at 6 months of age

hematopoietic system
enlarged spleen ( J:116157 )
• at 6 months of age
increased activated T cell number ( J:116157 )
• increased number of activated CD4 cells at 6 months of age
abnormal CD4-positive, alpha-beta T cell physiology ( J:116157 )
• increased production of IL-2, IL-10, and IFNG

growth/size/body
enlarged spleen ( J:116157 )
• at 6 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory