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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp63tm2Fmc
targeted mutation 2, Frank McKeon
MGI:3693853
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trp63tm2Fmc/Trp63tm2Fmc involves: BALB/c MGI:3706345


Genotype
MGI:3706345
hm1
Allelic
Composition
Trp63tm2Fmc/Trp63tm2Fmc
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2Fmc mutation (0 available); any Trp63 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• after exposure to 0.45 Gy radiation on P5, ovaries of mutants show no oocyte death compared to ~90% observed in wild-type and Trp53tm1Tyj homozygotes
• oocytes in primordial follicles are completely resistant to DNA damage-induced oocyte death





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory