All Phenotypes Slc17a6<tm1Kldr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc17a6^tm1Kldr
targeted mutation 1, Klas Kullander
MGI:3693864

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc17a6^tm1Kldr/Slc17a6^tm1Kldr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3694902
cn2	Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Th^tm1(cre)Te/Th⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4887826
cn3	Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Tg(PLAT-cre)116Sdu/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4887827
cn4	Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Tg(Trpv1-icre)1Kldr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4887828
cn5	Grpr^tm1Jfb/Grpr^tm1Jfb Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Th^tm1(cre)Te/Th⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4887830
cn6	Scn10a^tm2(cre)Jwo/Scn10a⁺ Slc17a6^tm1Kldr/Slc17a6^tm1Kldr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4887831

Allelic Composition	Slc17a6^tm1Kldr/Slc17a6^tm1Kldr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6^tm1Kldr mutation (1 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:116180 )

• viable and fertile

Allelic Composition	Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Th^tm1(cre)Te/Th⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6^tm1Kldr mutation (1 available); any Slc17a6 mutation (60 available)
Th^tm1(cre)Te mutation (1 available); any Th mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

excessive scratching ( J:167752 )

abnormal pain threshold ( J:167752 )

• mice display decreased responsiveness to radiant heat but response to mechanically-induced pain is not significantly different from wild-type controls

decreased chemically-elicited antinociception ( J:167752 )

• mice have decreased sensitivity to inflammatory pain induced by formalin injection, but response to mechanically-induced pain is not different from wild-type

increased thermal nociceptive threshold ( J:167752 )

• latency of withdrawal in hot plate tests is significantly greater than wild-type at both 52 and 48 degrees

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:167752 )

N	• plasma creatinine, urea, and tyroxine 4 levels are normal, with slightly elevated by still within normal range levels of alanine aminotransferase; this excludes a systemic disorder (chronic itch) as underlying the elevated scratching

integument

mixed cellular infiltration to dermis ( J:167752 )

• immune cells are found in the dermis in wounded areas indicative of prolonged scratching and rubbing

thick epidermis ( J:167752 )

• mice display thickened epidermis of psoriasiform type in wounded areas

skin lesions ( J:167752 )

• mice develop lesions (ulcerations) in the neck and upper back region

increased pruritus ( J:167752 )

• mice display a chronic itch behavior (display frequent scratching episodes)

• topical application of a histamine receptor antagonist significantly reduces scratching behavior; oral administration of a blood-brain barrier impermeant antihistamine causes a similar reduction in scratching

• topical administration of capsaicin reduces the itch phenotype

Allelic Composition	Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Tg(PLAT-cre)116Sdu/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6^tm1Kldr mutation (1 available); any Slc17a6 mutation (60 available)
Tg(PLAT-cre)116Sdu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

excessive scratching ( J:167752 )

increased thermal nociceptive threshold ( J:167752 )

• mice display decreased responsiveness to radiant heat

integument

increased pruritus ( J:167752 )

• mice display a chronic itch behavior (display frequent scratching episodes)

Allelic Composition	Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Tg(Trpv1-icre)1Kldr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6^tm1Kldr mutation (1 available); any Slc17a6 mutation (60 available)
Tg(Trpv1-icre)1Kldr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

excessive scratching ( J:167752 )

• scratching behavior is significantly elevated compared to controls

increased thermal nociceptive threshold ( J:167752 )

• mice show decreased thermal pain sensitivity, but mechanical pain and inflammatory pain sensitivities are not different from control

Allelic Composition	Grpr^tm1Jfb/Grpr^tm1Jfb Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Th^tm1(cre)Te/Th⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grpr^tm1Jfb mutation (1 available); any Grpr mutation (14 available)
Slc17a6^tm1Kldr mutation (1 available); any Slc17a6 mutation (60 available)
Th^tm1(cre)Te mutation (1 available); any Th mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

excessive scratching ( J:167752 )

• compound mutant mice show elevated scratching compared to wild-type but this is significantly reduced from that shown by mutants with intact Grpr function

Allelic Composition	Scn10a^tm2(cre)Jwo/Scn10a⁺ Slc17a6^tm1Kldr/Slc17a6^tm1Kldr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
Slc17a6^tm1Kldr mutation (1 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:167752 )

N	• mice show a non-significant tendency towards increased spontaneous scratching behavior as well as a similar tendency to decreased thermal pain response • in response to an exogenous pruritogen mice show elevated scratching although response is somewhat delayed

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