Allele Symbol Allele Name Allele ID |
Slc17a6tm1Kldr targeted mutation 1, Klas Kullander MGI:3693864 |
||||||||||||||||||||||||||||
Summary |
6 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice display decreased responsiveness to radiant heat but response to mechanically-induced pain is not significantly different from wild-type controls
|
• mice have decreased sensitivity to inflammatory pain induced by formalin injection, but response to mechanically-induced pain is not different from wild-type
|
• latency of withdrawal in hot plate tests is significantly greater than wild-type at both 52 and 48 degrees
|
N |
• plasma creatinine, urea, and tyroxine 4 levels are normal, with slightly elevated by still within normal range levels of alanine aminotransferase; this excludes a systemic disorder (chronic itch) as underlying the elevated scratching
|
• immune cells are found in the dermis in wounded areas indicative of prolonged scratching and rubbing
|
• mice display thickened epidermis of psoriasiform type in wounded areas
|
• mice develop lesions (ulcerations) in the neck and upper back region
|
• mice display a chronic itch behavior (display frequent scratching episodes)
• topical application of a histamine receptor antagonist significantly reduces scratching behavior; oral administration of a blood-brain barrier impermeant antihistamine causes a similar reduction in scratching
• topical administration of capsaicin reduces the itch phenotype
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice display decreased responsiveness to radiant heat
|
• mice display a chronic itch behavior (display frequent scratching episodes)
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• scratching behavior is significantly elevated compared to controls
|
• mice show decreased thermal pain sensitivity, but mechanical pain and inflammatory pain sensitivities are not different from control
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• compound mutant mice show elevated scratching compared to wild-type but this is significantly reduced from that shown by mutants with intact Grpr function
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice show a non-significant tendency towards increased spontaneous scratching behavior as well as a similar tendency to decreased thermal pain response
• in response to an exogenous pruritogen mice show elevated scratching although response is somewhat delayed
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|