Phenotypes associated with this allele

• Allele Symbol: Krt71^Mhdarco12
• Allele Name: Martin Hrabe de Angelis reduced coat 12
• Allele ID: MGI:3693873
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Krt71^Mhdarco12/Krt71^Mhdarco12	C3HeB/FeJ-Krt71^Mhdarco12	MGI:3695038
ht2	Krt71^Mhdarco12/Krt71^+	C3HeB/FeJ-Krt71^Mhdarco12	MGI:3695039

Genotype
MGI:3695038

hm1

• Allelic Composition: Krt71^Mhdarco12/Krt71^Mhdarco12
• Genetic Background: C3HeB/FeJ-Krt71^Mhdarco12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Phenotype of Krt71^Mhdarco12/⁺ or Krt71^Mhdarco12/Krt71^Mhdarco12 and Krt71^Mhdarco13/⁺ or Krt71^Mhdarco13/Krt71^Mhdarco13 mice.

integument

waved hair ( J:116206 )

• curl visible by P10

• becomes less pronounced by 3 months of age

abnormal hair follicle inner root sheath morphology ( J:116206 )

• irregular formation of Henle's and Huxley's layers

• areas of increased thickness in Henle's layer are associated with round structures

• intermediate keratin filaments in Henle's layer form large whorls with only very short linear filamentous structures

curly vibrissae ( J:116206 )

Genotype
MGI:3695039

ht2

• Allelic Composition: Krt71^Mhdarco12/Krt71⁺
• Genetic Background: C3HeB/FeJ-Krt71^Mhdarco12

Phenotype of Krt71^Mhdarco12/⁺ or Krt71^Mhdarco12/Krt71^Mhdarco12 and Krt71^Mhdarco13/⁺ or Krt71^Mhdarco13/Krt71^Mhdarco13 mice.

integument

waved hair ( J:116206 )

• curl visible by P10

• becomes less pronounced by 3 months of age

abnormal hair follicle inner root sheath morphology ( J:116206 )

• irregular formation of Henle's and Huxley's layers

• areas of increased thickness in Henle's layer are associated with round structures

• intermediate keratin filaments in Henle's layer form large whorls with short lengths of linear intermediate filament bundles

curly vibrissae ( J:116206 )