Phenotypes associated with this allele

• Allele Symbol: Ranbp2^{Gt(pGT0pfs)630Wcs}
• Allele Name: gene trap 630, William C Skarnes
• Allele ID: MGI:3693886
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ranbp2^Gt(pGT0pfs)630Wcs/Ranbp2^Gt(pGT0pfs)630Wcs	either: 129P2/OlaHsd-Ranbp2^Gt(pGT0pfs)630Wcs or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:3694780
ht2	Ranbp2^Gt(pGT0pfs)630Wcs/Ranbp2^+	129P2/OlaHsd-Ranbp2^Gt(pGT0pfs)630Wcs	MGI:3694781
ht3	Ranbp2^Gt(pGT0pfs)630Wcs/Ranbp2^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3694782

Genotype
MGI:3694780

hm1

• Allelic Composition: Ranbp2^{Gt(pGT0pfs)630Wcs}/Ranbp2^{Gt(pGT0pfs)630Wcs}
• Genetic Background: either: 129P2/OlaHsd-Ranbp2^{Gt(pGT0pfs)630Wcs} or (involves: 129P2/OlaHsd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:116134 )

• embryonic lethal, no data on the specific time of death provided

Genotype
MGI:3694781

ht2

• Allelic Composition: Ranbp2^{Gt(pGT0pfs)630Wcs}/Ranbp2⁺
• Genetic Background: 129P2/OlaHsd-Ranbp2^{Gt(pGT0pfs)630Wcs}

nervous system

abnormal nervous system physiology ( J:116134 )

• Background Sensitivity: reduced levels of ATP in the brain and retina only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

vision/eye

abnormal rod electrophysiology ( J:116134 )

• reduced a-wave and b-wave amplitudes

• reduction in b-wave responses is greater than that in a-wave responses

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:116134 )

• Background Sensitivity: slower weight gain beginning around 4 months of age when on a high fat diet only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

• however, no differences in food consumption are detected

impaired glucose tolerance ( J:116134 )

• Background Sensitivity: reduced rates of glucose clearance only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

• however, gluconeogenesis is similar to wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:116134 )

• Background Sensitivity: slower weight gain beginning around 4 months of age when on a high fat diet only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

• however, no differences in food consumption are detected

Genotype
MGI:3694782

ht3

• Allelic Composition: Ranbp2^{Gt(pGT0pfs)630Wcs}/Ranbp2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

nervous system

nervous system phenotype ( J:116134 )

N • Background Sensitivity: ATP levels in the brain and retina are similar to wild-type mice, unlike heterozygotes on an inbred 129P2/OlaHsd background

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:116134 )

N • Background Sensitivity: glucose clearance rates are similar to wild-type mice, unlike heterozygotes on an inbred 129P2/OlaHsd background

growth/size/body

growth/size/body region phenotype ( J:116134 )

N • Background Sensitivity: weight gain on a high fat diet is similar to wild-type mice, unlike heterozygotes on an inbred 129P2/OlaHsd background